Metabolic and Neurodegenerative Disorders: The Molecular and Cellular Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 12864
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent decades, the human life span has risen significantly, and the proportion of the aging population is constantly growing, presenting significant health and economic challenges. The risk of certain disorders, such as those related to neurodegeneration, stroke, obesity, and diabetes, is invariably increased by aging. In this Special Issue, the focus will be on molecular and cellular mechanisms of metabolic and neurodegenerative disorders, particularly diabetes, obesity, Alzheimer's diseases, stroke, vascular dementia, and Huntington’s disease. These diseases are characterized by gradual degeneration, by relatively unexplained pathogenic mechanisms, particularly neuronal circuits, and are devoid of valid therapeutic approaches. Precise awareness of the particular cell and molecular mechanisms underlying metabolic disorders and neurodegeneration is a priority for the scientific community in this scenario. This Special Issue aims to provide an overview of the main signaling pathways and molecules involved in the process of aging, highlighting their intimate connection with the onset of metabolic and neurodegenerative disorders.
This Special Issue highlights global research initiatives to examine causes, recognize biomarkers of diseases, and strategies/therapies that can alleviate the effects of diseases and reduce the social and economic effects of metabolic and neurodegenerative disorders. Original research and review papers on topics, including, but not limited to, the involvement and contribution of oxidative stress and inflammation in diabetes and obesity, new mechanisms involving neuroinflammation, oxidative stress, mitochondrial dysfunction in metabolic and neurodegenerative disorders, gut–brain interaction, and non-coding RNAs in metabolic and neurodegenerative disorders, are requested for this Special Issue. In addition, we hope to attract research aimed at identifying disease biomarkers for early diagnosis and innovative therapeutic methods or techniques to avoid the development of neurological disorders.
In short, the Special Issue welcomes high-quality studies that apply to cell and animal models.
Dr. Murali Vijayan
Guest Editor
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Keywords
- diabetes
- aging
- oxidative stress
- metabolism
- neurodegeneration
- mitochondrial dysfunction
- stroke
- Alzheimer’s disease
- RNA biology
- bioinformatics
- neuroinflammation
- oxidative stress
- microRNAs
- lncRNAs
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