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Implication of Nanoparticles in Cancer Therapy Research, 2nd Edition
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Implication of Nanoparticles in Cancer Therapy Research, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 8593

Special Issue Editors

Dr. Diana Savu

E-Mail Website
Guest Editor
Department of Life and Environmental Physics, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, 077125 Magurele, Romania
Interests: radioresistant cancer cell biology; tumor cell radiosensitization; DNA damage signaling; mitochondria–nucleus communication; radiation-induced bystander effects; radiation response biomarkers; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals
Dr. Roxana Cristina Popescu

E-Mail Website
Guest Editor
Department of Life and Environmental Physics, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, 077125 Magurele, Romania
Interests: thin films; biomaterials; materials chemistry; cancer research; biomedical engineering; microscopy; tumors; cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Clinically employed classical cancer therapies can cause unselective damage to healthy tissue. A growing body of research used nanotechnology to find strategies to overcome this disadvantage. Current research is focused on developing innovative therapies based on novel nanoparticles that enhance the therapeutic effect of chemotherapy and radiotherapy in order to reduce toxicity. Typical nanoparticles possess a wide range of physicochemical and biological properties including nano range size (less than 100 nm), a large surface area to volume ratio, specific structural properties, the ability to carry specific agents on their surface, the capacity to form stable interactions with ligands, the ability to overcome cellular or tissue barriers and to circulate in the blood for a long time, enhanced electrical conductivity, superparamagnetic behavior, the energy absorption, unique fluorescence properties. These features allow nanoparticles to facilitate drug delivery, multimodality treatment, and theranostics (combined therapy and diagnostic).

In this Special Issue, we expect contributions from a broad community of scientists working on developing new strategies based on nanoparticles to improve cancer chemotherapy/radiotherapy.

More published papers could be found in the closed Special Issue: Implication of Nanoparticles in Cancer Therapy Research.

Dr. Diana Savu
Dr. Roxana Cristina Popescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • nanoparticles
  • nanocarriers
  • drug delivery
  • cancer therapy

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Published Papers (4 papers)

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Research

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15 pages, 4387 KiB  
Article
Enhancing Proton Radiosensitivity of Chondrosarcoma Using Nanoparticle-Based Drug Delivery Approaches: A Comparative Study of High- and Low-Energy Protons
by Mihaela Tudor, Roxana Cristina Popescu, Ionela N. Irimescu, Ann Rzyanina, Nicolae Tarba, Anca Dinischiotu, Liviu Craciun, Tiberiu Relu Esanu, Eugeniu Vasile, Andrei Theodor Hotnog, Mihai Radu, Gennady Mytsin, Mona Mihailescu and Diana Iulia Savu
Int. J. Mol. Sci. 2024, 25(21), 11481; https://doi.org/10.3390/ijms252111481 - 25 Oct 2024
Viewed by 1009
Abstract
To overcome chondrosarcoma’s (CHS) high chemo- and radioresistance, we used polyethylene glycol-encapsulated iron oxide nanoparticles (IONPs) for the controlled delivery of the chemotherapeutic doxorubicin (IONPDOX) to amplify the cytotoxicity of proton radiation therapy. Human 2D CHS SW1353 cells were treated with [...] Read more.
To overcome chondrosarcoma’s (CHS) high chemo- and radioresistance, we used polyethylene glycol-encapsulated iron oxide nanoparticles (IONPs) for the controlled delivery of the chemotherapeutic doxorubicin (IONPDOX) to amplify the cytotoxicity of proton radiation therapy. Human 2D CHS SW1353 cells were treated with protons (linear energy transfer (LET): 1.6 and 12.6 keV/µm) with and without IONPDOX. Cell survival was assayed using a clonogenic test, and genotoxicity was tested through the formation of micronuclei (MN) and γH2AX foci, respectively. Morphology together with spectral fingerprints of nuclei were measured using enhanced dark-field microscopy (EDFM) assembled with a hyperspectral imaging (HI) module and an axial scanning fluorescence module, as well as scanning electron microscopy (SEM) coupled with energy-dispersive X-Ray spectroscopy (EDX). Cell survival was also determined in 3D SW3153 spheroids following treatment with low-LET protons with/without the IONPDOX compound. IONPDOX increased radiosensitivity following proton irradiation at both LETs in correlation with DNA damage expressed as MN or γH2AX. The IONPDOX–low-LET proton combination caused a more lethal effect compared to IONPDOX–high-LET protons. CHS cell biological alterations were reflected by the modifications in the hyperspectral images and spectral profiles, emphasizing new possible spectroscopic markers of cancer therapy effects. Our findings show that the proposed treatment combination has the potential to improve the management of CHS. Full article
(This article belongs to the Special Issue Implication of Nanoparticles in Cancer Therapy Research, 2nd Edition)
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Review

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20 pages, 11717 KiB  
Review
Solid Lipid Nanoparticles, an Alternative for the Treatment of Triple-Negative Breast Cancer
by Monserrat Llaguno-Munive, Maria Ines Vazquez-Lopez and Patricia Garcia-Lopez
Int. J. Mol. Sci. 2024, 25(19), 10712; https://doi.org/10.3390/ijms251910712 - 5 Oct 2024
Cited by 5 | Viewed by 2603
Abstract
Within the field of nanomedicine, which is revolutionizing cancer treatment, solid lipid nanoparticles (SLNs) have shown advantages over conventional chemotherapy when tested on cancer cells in preclinical studies. SLNs have proven to be an innovative strategy for the treatment of triple-negative breast cancer [...] Read more.
Within the field of nanomedicine, which is revolutionizing cancer treatment, solid lipid nanoparticles (SLNs) have shown advantages over conventional chemotherapy when tested on cancer cells in preclinical studies. SLNs have proven to be an innovative strategy for the treatment of triple-negative breast cancer cells, providing greater efficiency than existing treatments in various studies. The encapsulation of antineoplastic drugs in SLNs has facilitated a sustained, controlled, and targeted release, which enhances therapeutic efficiency and reduces adverse effects. Moreover, the surface of SLNs can be modified to increase efficiency. For instance, the coating of these particles with polyethylene glycol (PEG) decreases their opsonization, resulting in a longer life in the circulatory system. The creation of positively charged cationic SLNs (cSLNs), achieved by the utilization of surfactants or ionic lipids with positively charged structural groups, increases their affinity for cell membranes and plasma proteins. Hyaluronic acid has been added to SLNs so that the distinct pH of tumor cells would stimulate the release of the drug and/or genetic material. The current review summarizes the recent research on SLNs, focusing on the encapsulation and transport of therapeutic agents with a cytotoxic effect on triple-negative breast cancer. Full article
(This article belongs to the Special Issue Implication of Nanoparticles in Cancer Therapy Research, 2nd Edition)
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56 pages, 7459 KiB  
Review
Magnetic Hyperthermia in Glioblastoma Multiforme Treatment
by Veronica Manescu (Paltanea), Iulian Antoniac, Gheorghe Paltanea, Iosif Vasile Nemoianu, Aurel George Mohan, Aurora Antoniac, Julietta V. Rau, Stefan Alexandru Laptoiu, Petruta Mihai, Horia Gavrila, Abdel Rahim Al-Moushaly and Alin Danut Bodog
Int. J. Mol. Sci. 2024, 25(18), 10065; https://doi.org/10.3390/ijms251810065 - 19 Sep 2024
Cited by 1 | Viewed by 2256
Abstract
Glioblastoma multiforme (GBM) represents one of the most critical oncological diseases in neurological practice, being considered highly aggressive with a dismal prognosis. At a worldwide level, new therapeutic methods are continuously being researched. Magnetic hyperthermia (MHT) has been investigated for more than 30 [...] Read more.
Glioblastoma multiforme (GBM) represents one of the most critical oncological diseases in neurological practice, being considered highly aggressive with a dismal prognosis. At a worldwide level, new therapeutic methods are continuously being researched. Magnetic hyperthermia (MHT) has been investigated for more than 30 years as a solution used as a single therapy or combined with others for glioma tumor assessment in preclinical and clinical studies. It is based on magnetic nanoparticles (MNPs) that are injected into the tumor, and, under the effect of an external alternating magnetic field, they produce heat with temperatures higher than 42 °C, which determines cancer cell death. It is well known that iron oxide nanoparticles have received FDA approval for anemia treatment and to be used as contrast substances in the medical imagining domain. Today, energetic, efficient MNPs are developed that are especially dedicated to MHT treatments. In this review, the subject’s importance will be emphasized by specifying the number of patients with cancer worldwide, presenting the main features of GBM, and detailing the physical theory accompanying the MHT treatment. Then, synthesis routes for thermally efficient MNP manufacturing, strategies adopted in practice for increasing MHT heat performance, and significant in vitro and in vivo studies are presented. This review paper also includes combined cancer therapies, the main reasons for using these approaches with MHT, and important clinical studies on human subjects found in the literature. This review ends by describing the most critical challenges associated with MHT and future perspectives. It is concluded that MHT can be successfully and regularly applied as a treatment for GBM if specific improvements are made. Full article
(This article belongs to the Special Issue Implication of Nanoparticles in Cancer Therapy Research, 2nd Edition)
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21 pages, 1354 KiB  
Review
Dual Implications of Nanosilver-Induced Autophagy: Nanotoxicity and Anti-Cancer Effects
by Lidia Strużyńska
Int. J. Mol. Sci. 2023, 24(20), 15386; https://doi.org/10.3390/ijms242015386 - 20 Oct 2023
Cited by 8 | Viewed by 1779
Abstract
In recent years, efforts have been made to identify new anti-cancer therapies. Various types of nanomaterials, including silver nanoparticles (AgNPs), are being considered as an option. In addition to its well-known antibacterial activity, AgNPs exhibit cytotoxic potential in both physiological and cancer cells [...] Read more.
In recent years, efforts have been made to identify new anti-cancer therapies. Various types of nanomaterials, including silver nanoparticles (AgNPs), are being considered as an option. In addition to its well-known antibacterial activity, AgNPs exhibit cytotoxic potential in both physiological and cancer cells by inducing stress-mediated autophagy and apoptotic cell death. A rapidly growing collection of data suggests that the proper regulation of autophagic machinery may provide an efficient tool for suppressing the development of cancer. In this light, AgNPs have emerged as a potential anti-cancer agent to support therapy of the disease. This review summarizes current data indicating the dual role of AgNP-induced autophagy and highlights factors that may influence its protective vs. its toxic potential. It also stresses that our understanding of the cellular and molecular mechanisms of autophagy machinery in cancer cells, as well as AgNP-triggered autophagy in both normal and diseased cells, remains insufficient. Full article
(This article belongs to the Special Issue Implication of Nanoparticles in Cancer Therapy Research, 2nd Edition)
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