Cardiac Repair and Regeneration: From Pathogenesis to Therapeutic Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 3039
Special Issue Editors
2. Early Development, Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden
Interests: cardiomyocyte biology; cell cycle; cytokinesis; centrosome; microtubules; cardiomyocyte polyploidization; cardiomyocyte proliferation; pluripotent stem cell
Special Issue Information
Dear Colleagues,
The primary cause of decreased heart structure and function is often an incident resulting in the loss of cardiomyocytes, triggering compensatory hypertrophy, myocardial wall dilatation, increased tension, secondary cardiomyocyte death, and, ultimately, heart failure. Unlike newborn mice, newts, and zebrafish, humans lack the capacity for cardiac repair and regeneration due to terminal differentiation and post-mitotic programming in cardiomyocytes. Extensive efforts have thus focused on reversing cardiac damage to promote heart regeneration. This Special Issue highlights pathogenesis and cutting-edge therapeutic approaches, including the induction of pre-existing cardiomyocyte proliferation, stem-cell-based cardiac repair, the immune system's role in cardiac regeneration, the impact of micro and long noncoding RNAs, and the influence of the extracellular matrix and metabolism. By shedding light on these areas, this Special Issue aims to advance our understanding on these diseases and their therapeutic strategies.
Dr. Marina Leone
Dr. Olaf Bergmann
Guest Editors
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Keywords
- heart regeneration
- cardiomyocyte proliferation
- cell cycle
- ischemic heart disease
- myocardial infarction
- stem cells
- cardiac repair
- polyploidization
- tissue engineering
- immune cells
- metabolism
- cell death
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