New Insights into Proteomics and Applications in Molecular Diagnostics and Systems Biology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1200
Special Issue Editor
Interests: tandem mass spectrometry; quantitative proteomics; shotgun proteomics; functional proteomics; systems biology; small molecules; biomarker discovery; data analysis
Special Issue Information
Dear Colleagues,
In recent years, proteomics has revolutionizing our understanding of cellular processes, disease mechanisms and drug development. Some of the recent advances in proteomics approaches have propelled this field to the forefront of modern biology and medicine. Proteomics plays an essential role in deciphering the complex molecular machinery of living organisms. It explores the identity, structure, function and interactions of proteins, shedding light on their crucial roles in cellular functions and signaling pathways. Recent technological advancements include those in mass spectrometry, such as isobaric stable isotope labelling. The multiplexing capability of these reagents enables achieving deep proteome coverage for multiple samples. These innovations have paved the way for the discovery of novel biomarkers for diseases, providing valuable insights into early diagnosis and personalized medicine.
Furthermore, proteomics has been instrumental in elucidating the mechanisms underlying various diseases, including cancer, neurodegenerative disorders and infectious diseases. By identifying specific protein alterations associated with these conditions, researchers are now better equipped to develop targeted therapies and therapeutic interventions. Additionally, proteomics has fostered the emergence of systems biology, allowing scientists to integrate proteomic data with genomics, transcriptomics and metabolomics, creating a holistic view of biological systems. The application of proteogenomics helps elucidate the complex landscape of cancer mutations and potential therapeutic targets. Moreover, single-cell proteomics has also emerged as a cutting-edge approach, enabling the study of heterogeneity within cell populations and shedding light on developmental processes and disease pathogenesis.
In conclusion, proteomics has undergone transformative developments in recent years, empowering researchers with the tools and knowledge needed to unravel the complexities of life at the molecular level. As we delve into the remarkable progress and potential of proteomics, we gain a deeper appreciation for its significance in driving advancements in medicine, diagnostics and our overall comprehension of the biological world.
Dr. Paulo Marcelo
Guest Editor
Manuscript Submission Information
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Keywords
- mass spectrometry
- liquid chromatography
- tandem mass spectrometry (MS/MS)
- quantitative proteomics
- shotgun proteomics
- label-free quantification
- post-translational modifications
- protein–protein interactions
- proteogenomics
- single-cell proteomics
- data analysis
- bioinformatics
- functional proteomics
- phosphoproteomics
- glycoproteomics
- biomarker discovery
- top–down proteomics
- clinical applications
- disease proteomics
- systems biology
