Radiation and Photochemical Modifications in Proteins: Mechanistic Aspects and Applications 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 257
Special Issue Editors
Interests: radiation- and photo-induced radical processes in sulfur containing amino acids; peptides; nucleobases; heterocyclic compounds; long range electron transfer processes in peptides and proteins; oxidative stress; kinetics of free radicals; pulse radiolysis
Special Issues, Collections and Topics in MDPI journals
2. Center for Advanced Technology, Adam Mickiewicz University, Poznań, Poland
Interests: photophysics; photochemistry; radiation chemistry of organic compounds of biological interest; photo-induced chemical reactions in sulfur- or silicon-containing organic compounds of importance in biology and material chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Proteins are highly abundant cellular biomolecules and therefore are a major target when biological systems are irradiated or illuminated. Radiation- and photo-induced modifications in proteins are associated with changes in their structure and functions. Radiolysis (the initiation of reactions by high-energy radiation) and photolysis (the initiations of reactions by UV and visible light) were found as very valuable and powerful chemical tools for inducing and studying radical processes that are of particular interest in biology and life sciences. The use of the methods of radiolysis and photolysis has provided a wealth of data, especially about the kinetics of the oxidation by various free radicals and their mechanisms, the identification of transients formed, their lifetimes and the possibility to repair them by the so-called antioxidants. The detailed knowledge of free radical modifications in proteins is becoming of increasing importance connected with understanding of their mechanisms in the development of damage in proteins under conditions of oxidative and reductive stress, aging, the etiology of several cardiovascular and neurodegenerative diseases and inflammation processes. The availability of time-resolved techniques, high-end technologies and detection methods to monitor single or global radiation- and photo-induced modifications of proteins has increased enormously in recent years, giving a much better insight into post-translational modification. Many final products were already demonstrated as possibly useful for biomarkers. All these data about protein modification might be helpful to a proteomic approach.
The gathered articles in these special issue are expected to provide a reference for the recent development in this interdisciplinary and practical subject to radiation- and photochemists, organic, medicinal, and pharmaco chemists, molecular modeling chemists as well as to cellular biologists who are in the target audience.
Research articles and reviews related to these topics in protein chemistry and applications are welcome.
Prof. Dr. Krzysztof Bobrowski
Prof. Dr. Bronisław Marciniak
Guest Editors
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