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Environmentally Induced Oxidative Stress Toxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 3270

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Environmental Health and Prevention Research Unite, Graduate School of Pharmaceutical Sciences, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka, Yokohama 2450066, Japan
Interests: health and disease in humans and animals; risk assessment of cancer; reproduction; child development; objective methods for epidemiology; in vivo, in vitro and in silico; mechanism sciences; exposure sciences for food and drinking; use and application of stem cells in toxicology
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Special Issue Information

Dear Colleagues,

Oxidative stress is arguably the most common mechanism in the toxicology of environmental agents, unifying the action of broad classes of physicochemically disparate environmental pollutants, including oxidant gases, organic compounds, particulate surfaces, and metal ions. As advances in redox biology identify previously unrecognized targets for disruption by exposure to xenobiotics, redox toxicology has emerged as a new field of investigation. Environmental contaminants can induce oxidative stress on cells through mechanisms that are direct, indirect, or involve the disruption of metabolic or bioenergetic processes that are regulated by thiol redox switches.

This Special Issue aims to collect original research and review articles that address all aspects of environmental pollutants and their mechanisms of action linked with oxidative stress, inflammation, and cell death in human diseases or using animal models.

Prof. Dr. Hideko Sone
Guest Editor

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Keywords

  • oxidative stress
  • environmental toxicology
  • environmental contaminants
  • inflammation
  • cell death
  • animal models

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Published Papers (2 papers)

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Research

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13 pages, 3901 KiB  
Article
Accumulation of Alpha-Synuclein and Increase in the Inflammatory Response in the substantia nigra, Jejunum, and Colon in a Model of O3 Pollution in Rats
by Marlen Valdés-Fuentes, Erika Rodríguez-Martínez and Selva Rivas-Arancibia
Int. J. Mol. Sci. 2024, 25(10), 5526; https://doi.org/10.3390/ijms25105526 - 18 May 2024
Cited by 1 | Viewed by 1030
Abstract
This work aimed to study the effect of repeated exposure to low doses of ozone on alpha-synuclein and the inflammatory response in the substantia nigra, jejunum, and colon. Seventy-two male Wistar rats were divided into six groups. Each group received one of [...] Read more.
This work aimed to study the effect of repeated exposure to low doses of ozone on alpha-synuclein and the inflammatory response in the substantia nigra, jejunum, and colon. Seventy-two male Wistar rats were divided into six groups. Each group received one of the following treatments: The control group was exposed to air. The ozone groups were exposed for 7, 15, 30, 60, and 90 days for 0.25 ppm for four hours daily. Afterward, they were anesthetized, and their tissues were extracted and processed using Western blotting, immunohistochemistry, and qPCR. The results indicated a significant increase in alpha-synuclein in the substantia nigra and jejunum from 7 to 60 days of exposure and an increase in NFκB from 7 to 90 days in the substantia nigra, while in the jejunum, a significant increase was observed at 7 and 15 days and a decrease at 60 and 90 days for the colon. Interleukin IL-17 showed an increase at 90 days in the substantia nigra in the jejunum and increases at 30 days and in the colon at 15 and 90 days. Exposure to ozone increases the presence of alpha-synuclein and induces the loss of regulation of the inflammatory response, which contributes significantly to degenerative processes. Full article
(This article belongs to the Special Issue Environmentally Induced Oxidative Stress Toxicology)
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Review

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21 pages, 1858 KiB  
Review
Pathological Mechanisms of Particulate Matter-Mediated Ocular Disorders: A Review
by Jung-Hwa Han, Chaima Amri, Hyesook Lee and Jin Hur
Int. J. Mol. Sci. 2024, 25(22), 12107; https://doi.org/10.3390/ijms252212107 - 11 Nov 2024
Cited by 2 | Viewed by 1726
Abstract
Air pollution presents a severe risk to public health, with particulate matter (PM) identified as a significant hazardous element. However, despite the eye organ being constantly exposed to air pollution, only recently has the impact of PM on ocular health caught the attention [...] Read more.
Air pollution presents a severe risk to public health, with particulate matter (PM) identified as a significant hazardous element. However, despite the eye organ being constantly exposed to air pollution, only recently has the impact of PM on ocular health caught the attention of researchers and healthcare professionals. By compiling pertinent data, this paper aims to enhance our understanding of the underlying pathological mechanisms of PM-mediated ocular disorders and facilitate the development of effective treatment strategies. Recent data support the association between exposure to PM and the development of ocular pathologies such as dry eye syndrome, retinal atherosclerosis, and glaucoma. Based on the results of multiple studies, PM exposure can lead to oxidative stress, inflammation, autophagy, cell death, and, ultimately, the development of ophthalmic diseases. This review aims to consolidate the latest findings on PM-mediated ocular diseases by summarizing the outcomes from epidemiological, in vitro, and in vivo studies on ocular surface and retinal disorders as well as other relevant ophthalmic disorders. Full article
(This article belongs to the Special Issue Environmentally Induced Oxidative Stress Toxicology)
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