Lipid Metabolism in Aging and Diseases: From Mechanisms to Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 10
Special Issue Editor
2. INSERM Research Center U1231—Therapies and Immune Response in Cancers Team, Bioactive Molecules and Health Research Group, F-21000 Dijon, France
3. Centre de Lutte contre le Cancer Georges François Leclerc Center, F-21000 Dijon, France
4. Inserm US58 Biologie Santé Dijon (BioSanD), F-21000 Dijon, France
Interests: bioactive molecules; cancer; metabolism; cell death; chemoresistance; age-related degenerative diseases; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alterations in lipid metabolism are increasingly recognized as a central feature in the pathophysiology of major chronic and age-related diseases. Beyond its role in energy storage and membrane composition, lipid metabolism influences cell signaling, inflammation, oxidative stress, and mitochondrial function, processes critically involved in disease onset and progression. Dysregulation of lipid pathways contributes to cardiovascular disorders, chronic inflammatory conditions, autoimmune diseases, cancers, and age-related degenerative diseases (i.e., Alzheimer’s, Parkinson’s, Huntington’s disease, amyotrophic lateral sclerosis (ALS), and ocular degeneration). Other age-associated conditions, including type 2 diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), sarcopenia, osteoporosis, and chronic kidney disease, are also strongly linked to lipid imbalance.
Recent evidence highlights that lipid remodeling, including lipid droplet accumulation, phospholipid imbalance, altered fatty acid desaturation, and lipid peroxidation, can drive cellular dysfunction and exacerbate degenerative processes. These lipid-related changes not only serve as biomarkers of disease progression but also represent promising therapeutic targets. Strategies such as bioactive molecules and drug repositioning offer new opportunities to modulate lipid metabolism and restore cellular homeostasis, representing a major challenge and an exciting frontier in translational research.
This Special Issue aims to gather original research and comprehensive reviews addressing the impact of lipid metabolism on age-related degenerative diseases, with a focus on mechanistic insights, therapeutic interventions, and future perspectives.
Prof. Dr. Dominique Delmas
Guest Editor
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Keywords
- lipid metabolism
- degenerative diseases
- cardiovascular pathologies
- neurodegeneration
- inflammation
- autoimmunity
- cancer
- lipid droplets
- bioactive molecules
- drug repositioning
- oxidative stress
- mitochondrial dysfunction
- inflammatory processes
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