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Photobiology and Medical Biomaterials Research
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Photobiology and Medical Biomaterials Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 7835

Special Issue Editors

Prof. Dr. Cuiping Yao

E-Mail Website
Guest Editor
Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
Interests: optical diagnosis and treatment methods and applications; machine learning-assisted optical imaging and diagnosis
Prof. Dr. Zhenxi Zhang

E-Mail Website
Guest Editor
Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
Interests: biomedicine and molecular photonics; photobiophysics and medical biomaterials and technologies

Special Issue Information

Dear Colleagues,

With the development of laser technology and its precision, optical technologies for molecular detection and regulation have matured and been widely applied in the biomedical field including biomacromolecule manipulation and modification, biomedical imaging and sensors, disease diagnosis and therapies, nerve and immune regulation, etc. Thus, it is necessary to further clarify the interaction mechanism between light and biomolecules, develop more relevant optical technologies, and expand their applications within the clinical setting. In this Special Issue, we invite optical and biomedical specialties, doctors interested in clinical research, researchers in materials science, and all the experts conducting relevant studies to contribute your original research articles or relevant reviews on this topic. The key topics of this Special Issue include, but are not limited to, the principles and mechanisms, devices and systems, and clinical or biomedical applications such as:

  • Optical bioimaging technologies, such as photoacoustic imaging, OCT, hyperspectral imaging, endoscopic imaging, and so on;
  • Optical therapeutic technologies, such as photodynamic therapy, photothermal therapy, photoimmunotherapy, light-triggered drug delivery, and so on;
  • Optical biosensing technologies, including surface-enhanced Raman spectroscopy, fluorescence, chemiluminescence, luminescence, and so on;
  • Photo-driven molecule manipulation, modification, or regulation, such as optical tweezers, photogenetic, photo-cavitation, and so on;
  • Clinical and biomedical applications based on optical devices or systems.

We welcome you to submit your contributions to this prestigious journal. Thank you very much for your attention, and we look forward to your involvement in the Special Issue.

Prof. Dr. Cuiping Yao
Prof. Dr. Zhenxi Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phototherapy
  • photogenetics
  • photoregulation
  • photobiological materials

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Published Papers (3 papers)

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Research

20 pages, 5389 KiB  
Article
Chlorin E6-Curcumin-Mediated Photodynamic Therapy Promotes an Anti-Photoaging Effect in UVB-Irradiated Fibroblasts
by Til Bahadur Thapa Magar, Shyam Kumar Mallik, Pallavi Gurung, Junmo Lim, Young-Tak Kim, Rajeev Shrestha and Yong-Wan Kim
Int. J. Mol. Sci. 2023, 24(17), 13468; https://doi.org/10.3390/ijms241713468 - 30 Aug 2023
Cited by 9 | Viewed by 2435
Abstract
Skin photoaging due to ultraviolet B (UVB) exposure generates reactive oxygen species (ROS) that increase matrix metalloproteinase (MMP). Chlorin e6-photodynamic therapy (Ce6-PDT), in addition to being the first-line treatment for malignancies, has been shown to lessen skin photoaging, while curcumin is well known [...] Read more.
Skin photoaging due to ultraviolet B (UVB) exposure generates reactive oxygen species (ROS) that increase matrix metalloproteinase (MMP). Chlorin e6-photodynamic therapy (Ce6-PDT), in addition to being the first-line treatment for malignancies, has been shown to lessen skin photoaging, while curcumin is well known for reducing the deleterious effects of ROS. In the current study, PDT with three novel Ce6-curcumin derivatives, a combination of Ce6 and curcumin with various linkers, including propane-1,3-diamine for Ce6-propane-curcumin; hexane-1,6-diamine for Ce6-hexane-curcumin; and 3,3′-((oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine) for Ce6-dipolyethylene glycol (diPEG)-curcumin, were studied for regulation of UVB-induced photoaging on human skin fibroblast (Hs68) and mouse embryonic fibroblast (BALB/c 3T3) cells. We assessed the antiphotoaging effects of Ce6-curcumin derivatives on cell viability, antioxidant activity, the mechanism of matrix metalloproteinase-1 and 2 (MMP-2) expression, and collagen synthesis in UVB-irradiated in vitro models. All three Ce6-curcumin derivatives were found to be non-phototoxic in the neutral red uptake phototoxicity test. We found that Ce6-hexane-curcumin-PDT and Ce6-propane-curcumin-associated PDT exhibited less cytotoxicity in Hs68 and BALB/c 3T3 fibroblast cell lines compared to Ce6-diPEG-curcumin-PDT. Ce6-diPEG-curcumin and Ce6-propane-curcumin-associated PDT showed superior antioxidant activity in Hs68 cell lines. Further, in UVB-irradiated in vitro models, the Ce6-diPEG-curcumin-PDT greatly attenuated the expression levels of MMP-1 and MMP-2 by blocking mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1), and tumor necrosis factor-α (NF-κB) signaling. Moreover, Ce6-diPEG-curcumin effectively inhibited inflammatory molecules, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, while accelerating collagen synthesis. These results demonstrate that Ce6-diPEG-curcumin may be a potential therapy for treating skin photoaging. Full article
(This article belongs to the Special Issue Photobiology and Medical Biomaterials Research)
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15 pages, 3130 KiB  
Article
Improved Simulated-Daylight Photodynamic Therapy and Possible Mechanism of Ag-Modified TiO2 on Melanoma
by Jing Xin, Jing Wang, Yuanping Yao, Sijia Wang, Zhenxi Zhang and Cuiping Yao
Int. J. Mol. Sci. 2023, 24(8), 7061; https://doi.org/10.3390/ijms24087061 - 11 Apr 2023
Cited by 4 | Viewed by 2222
Abstract
Simulated-daylight photodynamic therapy (SD-PDT) may be an efficacious strategy for treating melanoma because it can overcome the severe stinging pain, erythema, and edema experienced during conventional PDT. However, the poor daylight response of existing common photosensitizers leads to unsatisfactory anti-tumor therapeutic effects and [...] Read more.
Simulated-daylight photodynamic therapy (SD-PDT) may be an efficacious strategy for treating melanoma because it can overcome the severe stinging pain, erythema, and edema experienced during conventional PDT. However, the poor daylight response of existing common photosensitizers leads to unsatisfactory anti-tumor therapeutic effects and limits the development of daylight PDT. Hence, in this study, we utilized Ag nanoparticles to adjust the daylight response of TiO2, acquire efficient photochemical activity, and then enhance the anti-tumor therapeutic effect of SD-PDT on melanoma. The synthesized Ag-doped TiO2 showed an optimal enhanced effect compared to Ag-core TiO2. Doping Ag into TiO2 produced a new shallow acceptor impurity level in the energy band structure, which expanded optical absorption in the range of 400–800 nm, and finally improved the photodamage effect of TiO2 under SD irradiation. Plasmonic near-field distributions were enhanced due to the high refractive index of TiO2 at the Ag-TiO2 interface, and then the amount of light captured by TiO2 was increased to induce the enhanced SD-PDT effect of Ag-core TiO2. Hence, Ag could effectively improve the photochemical activity and SD-PDT effect of TiO2 through the change in the energy band structure. Generally, Ag-doped TiO2 is a promising photosensitizer agent for treating melanoma via SD-PDT. Full article
(This article belongs to the Special Issue Photobiology and Medical Biomaterials Research)
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13 pages, 27383 KiB  
Article
PI4P-Containing Vesicles from Golgi Contribute to Mitochondrial Division by Coordinating with Polymerized Actin
by Xinxin Duan, Yunfei Wei, Meng Zhang, Wenting Zhang, Yue Huang and Yu-Hui Zhang
Int. J. Mol. Sci. 2023, 24(7), 6593; https://doi.org/10.3390/ijms24076593 - 1 Apr 2023
Cited by 10 | Viewed by 2237
Abstract
Golgi-derived PI4P-containing vesicles play important roles in mitochondrial division, which is essential for maintaining cellular homeostasis. However, the mechanism of the PI4P-containing vesicle effect on mitochondrial division is unclear. Here, we found that actin appeared to polymerize at the contact site between PI4P-containing [...] Read more.
Golgi-derived PI4P-containing vesicles play important roles in mitochondrial division, which is essential for maintaining cellular homeostasis. However, the mechanism of the PI4P-containing vesicle effect on mitochondrial division is unclear. Here, we found that actin appeared to polymerize at the contact site between PI4P-containing vesicles and mitochondria, causing mitochondrial division. Increasing the content of PI4P derived from the Golgi apparatus increased actin polymerization and reduced the length of the mitochondria, suggesting that actin polymerization through PI4P-containing vesicles is involved in PI4P vesicle-related mitochondrial division. Collectively, our results support a model in which PI4P-containing vesicles derived from the Golgi apparatus cooperate with actin filaments to participate in mitochondrial division by contributing to actin polymerization, which regulates mitochondrial dynamics. This study enriches the understanding of the pathways that regulate mitochondrial division and provides new insight into mitochondrial dynamics. Full article
(This article belongs to the Special Issue Photobiology and Medical Biomaterials Research)
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