Molecular and Cellular Research in Pregnancy-Related Complications, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 October 2025) | Viewed by 13069
Special Issue Editor
Interests: extracellular matrix; pregnancy loss; thrombophilia; polymorphism; biomaterials; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Reproductive complications, maternal and fetal morbidity, and mortality are common attributes of non-favorable pregnancies. The detection of at-risk pregnancies in early gestation is a challenging task for developing corrective and curative strategies.
Biomarkers in maternal circulation have been explored to evaluate risk in early pregnancy, but thus far, they are only reliable for the diagnostics of rather limited pregnancy complications.
Recent studies highlight the role of systemic and placental oxidative stress as an essential factor in the etiology of early pregnancy losses. Trophoblast invasion under low-oxygen conditions and hypoxia-induced oxidative stress are important regulators of the physiological development of the placenta and embryo in early pregnancy. Nonetheless, when oxidative stress exceeds the normal physiological level in the maternal–fetal environment, orchestrated by blood cell damage, accelerated senescence and early eryptosis, complications such as miscarriage, pre-eclampsia and limited intrauterine development may occur.
The imbalance of immune tolerance at the maternal–fetal interface is another important factor in the occurrence of pregnancy loss. The immunologic events at the maternal–fetal interface in early pregnancy are complex, involving numerous immune cells and molecules.
A promising approach for investigation of the placenta and placental–fetus interaction comes from the fact that trophoblast cells could migrate from the placenta into the reproductive tract, and could then be collected and separated from maternal cells for the analysis of fetal proteins, DNA, RNA and other informative molecules.
This Special Issue aims at expanding the current knowledge on the structural and behavioral imbalance of peripheral and endometrial immune cells, red blood cells, trophoblasts, decidual cells and stem cells in pregnancy-related complications. Experimental studies and reviews are welcome for submission.
More published papers can be found in the closed Special Issue “Molecular and Cellular Research in Pregnancy-Related Complications”.
Prof. Dr. Regina Komsa-Penkova
Guest Editor
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Keywords
- pregnancy loss/miscarriage
- pregnancy complications
- pre-eclampsia
- maternal–placental–fetal interactions
- trophoblast
- immune cells
- immune tolerance
- red blood cells
- oxidative stress
- blood and fetal proteins
- DNA
- RNA
- stem cells
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