Pathophysiological and Molecular Signaling Impacts of Chronic Hypoxia and Intermittent Hypoxia
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 12352
Special Issue Editors
Interests: cardiovascular physiology; elastic fibers in vascular development, genetic diseases and aging; intermittent hypoxia-induced cardiovascular dysfunction; biomechanics; elastin receptors; calcium signalling; pharmacotherapy
Special Issues, Collections and Topics in MDPI journals
Interests: obstructive sleep apnea; obesity hypoventilation syndrome; central sleep apnea; coronary artery bypass graft (CABG); heart bypass surgery
Special Issue Information
Dear Colleagues,
Changes—especially limitations—in the oxygenation of an organism have important impacts on organ function and the general physiology. Two major situations impact oxygenation: i) chronic hypoxia (CH), due to pathological situations chronically limiting blood oxygenation such as chronic obstructive pulmonary diseases, including emphysema, or life at high altitudes; and ii) intermittent hypoxia (IH), due to the intermittent obstruction of the upper airways, especially related to sleep apnea (obstructive sleep apnea syndrome). These two conditions both induce hypoxemia, with consequences on most systems, including the cardiovascular, pulmonary and nervous systems, as well as the metabolism and associated organs/tissues (liver, fat, etc.). However, some CH and IH pathophysiological impacts are rather similar (hematocrit elevation, the activation of hypoxia-inducible factor (HIF) pathways, etc.), while other impacts are divergent (pulmonary hypertension in CH, systemic hypertension in IH, distinct patterns of HIF activation in IH and CH, etc.). Additionally, some CH and IH impacts could be seen as beneficial for the organism (e.g., preconditioning limiting the severity of further cardiovascular events), while other effects are clearly deleterious (e.g., higher risk of cardiac infarct in IH). Thus, this Special Issue intends to collect the latest results on the physiopathological consequences of chronic hypoxia or intermittent hypoxia, allowing for a better understanding, as well as a dissection of the downstream cellular and molecular mechanisms involved in the structural and functional changes observed in concerned persons, patients or animal models. We hope this compilation of works permits a reflection and better understanding of the similarities and differences of the mechanisms and impacts of CH and IH. Experimental papers and review articles in basic science, clinical or translational fields are welcome.
Prof. Dr. Gilles Faury
Prof. Dr. Jean Louis D. Peṕin
Dr. Samuel Verges
Guest Editors
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Keywords
- intermittent hypoxia
- chronic hypoxia
- sleep apnea
- altitude
- hypoxia-induced factor
- signaling pathways
- cardiovascular system
- metabolism
- pulmonary system
- nervous system
- disease
- preconditioning
- patients
- animal models
- cellular models
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