New Insights into Inflammasomes 2.0

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, "New Insights into Inflammasomes".

Inflammasomes are cytosolic caspase-1-containing protein complexes that recognize and respond to pathogen infection as well as diverse sterile host-derived or environmental danger signals to promote inflammatory disease development. The activation of inflammasomes leads to caspase-1-dependent maturation, the release of the proinflammatory cytokines IL-1β and IL-18, and promotes Gasdermin D-dependent pyroptotic cell death. The dysregulation of inflammasomes is associated with a number of inflammatory conditions, such as COVID-19, metabolic disorders, diabetes, cardiovascular diseases, neurodegenerative diseases, inflammatory bowel disease, kidney injury, and infectious diseases. As inflammasomes respond to a broad range of medically relevant stimuli, inflammasomes have become a highly desirable drug target with which to treat a wide range of human diseases. Small-molecule inhibitors targeting inflammasomes offer a new therapeutic strategy in new drug development. This Special Issue, “New Insights into Inflammasomes”, welcomes original research and review articles in the field, with a focus on, but not limited to, the molecular and mechanistic bases for inflammasome activation, inflammasome-associated pathogenesis, inflammasome inhibitor development, and inflammasome-specific therapeutics.

Prof. Dr. Kuo-Feng Hua
Guest Editor

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