New Insight into Anticoagulants
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4536
Special Issue Editor
Special Issue Information
Dear Colleagues,
Anticoagulants represent an impressive example of effective drugs that continue to inspire further molecular-level research. Several studies have suggested that anticoagulants not only affect the coagulation mechanism, but also possess a wide range of pharmacological properties, such as antithrombotic, profibrinolytic, and lipid-lowering activities. These drugs are used in clinical practice for the prevention and therapy of deep vein thrombosis, pulmonary embolism, stroke prevention and in the management of arterial thrombosis, together with plateled inhibitors. Recently, anticoagulants were associated with an improvement in the therapy for venous leg ulcers, proteinuria, various inflammatory disorders and cardiovascular disease in diabetes patients. New evidence suggests that anticoagulants can be used as drugs to prevent COVID-19-induced vascular complications. Although anticoagulants have been available on the pharmaceutical market for decades, a great amount of research into their molecular mechanisms of action is ongoing. In an attempt to explain the pleiotropic effects of anticoagulants, a number of targeting molecules involved in apoptosis, autophagy, oxidative stress, inflammation, metastasis and angiogenesis have been discovered.
This Special Issue aims to attract papers that report recent evidence and views on anticoagulants, and which describe new potential molecular mechanisms of action of these drugs.
Research papers and reviews on the above-mentioned topics are particularly welcome.
Prof. Dr. Bożena Gabryel
Guest Editor
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Keywords
- anticoagulants
- antioxidant properties
- cytoprotection
- endothelium
- anti-inflammatory effects
- infections
- cancer metastasis
- angiogenesis
- apoptosis
- autophagy
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