Engineered Probiotics in the Treatment of Inflammatory Bowel Disease, Cancer, Infections, and Metabolic Disorders

Dear Colleagues,

It has long been known that the gut microflora plays a significant role in human health, and dysbiosis of it has been linked to a number of diseases. Probiotics are defined by the World Health Organization and the Food and Agriculture Organization of the United Nations as “live microorganisms which when administered in adequate amounts confer a health benefit on the host”. With the recent advancements in genome sequencing technology and the potency of some genome editing and modification techniques, we can now engineer probiotics to our own specifications and create personalized probiotics. Probiotics can be genetically engineered to have a wide range of advantageous qualities and to treat particular disorders, both of which are good for human health. Research on the genetic engineering of microbial strains, including probiotics, seems promising. This Special Issue aims to present techniques for producing altered probiotics, the scientific basis for gene editing technology, the mode of action of these modified probiotics, and their potential applications in the treatment of bacterial infections, cancer, inflammatory bowel disease, and other metabolic disorders.

Dr. Yash Gupta
Prof. Dr. Oliana Carnevali
Guest Editors

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• CRISPR
• GMO
• Lactobacillus
• yeast
• Bifidobacterium
• tight junctions
• inflammatory cascade
• IBS
• Clostridium
• Entamoeba
• colorectal cancer
• pancreatic cancer