Molecular Advances in Protein-Ligand Interactions

Dear Colleagues,

Protein–protein and protein–ligand interactions are at the center stage of the cellular processes and regulatory mechanisms of living systems. Spanning a spectrum from well-folded to intrinsically disordered proteins, these interactions serve as a basis for molecular recognition and facilitation of transient and stable interactions within the cellular communication pathways. Examination of these interactions identifies the key players and elucidates mechanisms that are essential for maintaining homeostasis under normal physiological conditions. Ultimately, this knowledge can be translated into probing biomolecular interactions in the context of pathological states, many of which involve proteins and their ligands. This approach expands our fundamental understanding and illuminates approaches for the development of novel treatments for various medical conditions. Technical advances and new methodologies accelerate these efforts, broaden the scope of the investigations, and provide transformational perspectives. For this Special Issue of IJMS, we aim to collect contributions in the form of either original research articles or reviews to add new insight into the role of protein–protein and protein–ligand interactions in biological processes. We seek to highlight the state of the art, challenges, and open issues in this field of investigation. We are also looking for contributions underlining the impact of the investigated processes in biomedicine and molecular pathology, as well as applications of protein–protein and protein–ligand interactions in food industry and biotechnology.

Dr. Ewa A. Bienkiewicz
Guest Editor

Manuscript Submission Information

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• protein-protein interactions
• protein-ligand interactions
• multiomics
• artificial intelligence (AI)
• biophysics
• molecular biology
• disease