New Insights into Overcoming Oxidative Stress in Neuropathology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 25 April 2026
Special Issue Editor
Interests: neurobiology; cell biology; cell ultrastructure; oxidative stress; inflammation; cell death mechanisms; mycotherapy; phytotherapy; new psychoactive substances (NPS); neurodegenerative diseases; breast cancer; aging; senescence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress is increasingly recognized as a central mechanism driving the onset and progression of various neuropathological conditions. The imbalance between the production of reactive oxygen and nitrogen species and the efficiency of endogenous antioxidant defenses leads to extensive molecular and cellular damage within the central and peripheral nervous systems. This redox imbalance contributes to neuronal dysfunction, glial activation, neuroinflammation, and ultimately to neurodegeneration. Understanding the complex interplay between oxidative mechanisms, mitochondrial activity, and cellular metabolism represents one of the major challenges in contemporary neuroscience.
This Special Issue of the International Journal of Molecular Sciences, “New Insights into Overcoming Oxidative Stress in Neuropathology” (edited by Dr. Ludovica Gaiaschi and supported Dr. Fabrizio De Luca), highlights the most recent advances in our understanding of redox biology in the nervous system and its contribution to neuropathological processes. We particularly welcome studies exploring the mechanistic basis of oxidative injury, identifying novel biomarkers, and developing innovative pharmacological, nutraceutical, and molecular strategies to counteract oxidative damage in neuropathological conditions.
Topics of interest include, but are not limited to, the following:
- Molecular and cellular mechanisms of oxidative damage in neuropathological conditions;
- Comparative and translational models of redox imbalance in neuropathology;
- Neurotoxic and neuroprotective mechanisms mediated by oxidative stress;
- Novel antioxidant, pharmacological, and nutraceutical approaches;
- Redox-sensitive biomarkers for early diagnosis, prognosis, or therapeutic monitoring;
- Mitochondrial dysfunction and redox regulation in neuronal and glial populations;
- Redox-omics and precision approaches to characterise oxidative signatures in neuropathology;
- Extracellular vesicles and redox signalling in neuroinflammation and neurodegeneration;
- Age-/sex-related redox imbalance and cellular senescence in neuropathological disorders;
- Microbiota–brain axis and redox homeostasis in neuropathology.
We welcome original research articles, short communications, reviews, and case reports addressing these aspects of oxidative stress in neuropathology.
Dr. Fabrizio De Luca
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- neuropathology
- neurodegeneration
- molecular and cellular alterations
- central and peripheral nervous systems
- neuronal dysfunction
- glial activation
- neuroinflammation
- mitochondrial activity
- cellular metabolism
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
