Latest Applications of Next-Generation Sequencing and Whole-Genome Sequencing in Molecular Biology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1083
Special Issue Editor
Special Issue Information
Dear Colleagues,
It will soon be 20 years since the advent of massively parallel sequencing (MPS) technology and the introduction of the first devices enabling the acquisition of large quantities of nucleic acid sequences in a relatively short time and at a low cost. Over these years, the technology has evolved, creating new research possibilities and becoming accessible to a broad community of researchers. As a result, sequence databases are expanding at an unprecedented rate. This technological revolution has also brought a widening range of applications for MPS techniques. An important aspect of this process is the diversity of available large-scale sequencing technologies, which allows for tailoring the chosen technology to the research objective and compiling data obtained using various technologies to enhance the quality of results or their validation.
The substantial progress in sequencing technology also underlies significant shifts in our understanding of processes occurring within living organisms, particularly at the molecular level. The ability to elucidate complete genome sequences or their selected segments, coupled with technologies enabling the analysis of the expression of entire gene sets and the detection of various types of polymorphisms, at both the single-nucleotide and whole-chromosome levels, has led to a proliferation of publications detailing the workings of specific molecular mechanisms underlying the functioning of living organisms.
Our aim in preparing this Special Issue is to compile scientific articles describing various aspects of the applications of large-scale sequencing technology in molecular biology research. We are particularly keen on presenting publications that showcase methods and experimental approaches that ingeniously and pioneeringly harness the potential of available devices, setting new trends in the utilization of MPS technology within the field of molecular biology.
Dr. Marcin Woźniak
Guest Editor
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Keywords
- next-generation sequencing
- whole-genome sequencing
- molecular biology
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