Human Carbonic Anhydrase Family as Target for Drug Design

Dear Colleagues, 

Human Carbonic Anhydrases (hCAs) are zinc enzymes that act as catalysts in the reversible hydration of carbon dioxide to bicarbonate and proton. Up to now, fifteen isoforms have been identified, which differ in terms of kinetic properties, response to inhibitors, cellular localization and pattern of expression in various tissues. In recent years, these enzymes have become an interesting target for the design of inhibitors or activators with biomedical applications. Indeed, several studies have demonstrated the important roles of hCAs in a variety of physiological processes and showed that abnormal levels and/or activities of these enzymes are often associated with different human diseases such as glaucoma, osteoporosis, neurological disorders, cancer, etc.  In this Special Issue, we will summarize the most important results obtained in this field and provide future perspectives for the development of novel drug classes targeting hCAs.

Dr. Vincenzo Alterio
Dr. Anna Di Fiore
Dr. Giuseppina De Simone 
Guest Editors

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