Renal Tumors: Molecular Biology and Therapeutic Vulnerabilities
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 39
Special Issue Editor
Interests: renal cell carcinoma; molecular genetics; clinical trials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Renal neoplasms are a group of renal tumors arising from the nephron arising from a wide of genetic alterations. Many forms of kidney cancer have unique biology, but many have overlapping metabolic dysregulation in pathways regulating oxygen sensing, iron metabolism, and energy/nutrient sensing. Both sporadic and hereditary forms of kidney cancer contain genetic alterations that are often overlapping. Benign renal tumors also have unique biology with defects in mitochondrial biology, as well as the TSC/mTOR pathway. Prognosis is extremely variable, as tumors range from indolent with no potential to harm patients to extremely aggressive being refractory to most treatments. This Special Issue will contain translational research focus on various types of renal tumors, both malignant and benign, with special emphasis on preclinical models, genetic characteristics, methods for prognostication, molecular imaging, and novel approaches for therapeutic targeting.
Prof. Dr. Brian Shuch
Guest Editor
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Keywords
- renal cell carcinoma
- neoplasia
- VHL
- tumor suppressor
- predisposition
- oncocytoma
- transcriptomics
- metabolism
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