ijms-logo

Journal Browser

Journal Browser

Strategies to Counteract Oxidative Stress and Inflammation in Chronic-Degenerative Diseases, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 2654

Special Issue Editors


E-Mail Website
Guest Editor
Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Interests: nutritional biochemistry; neurodegenerative diseases; oxidative stress; inflammation; nutraceuticals; aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The great increase in life expectancy is linked to the necessity of counteracting chronic degenerative diseases, e.g., cancer, metabolic syndrome, type 2 diabetes, and cardiovascular as well as neurodegenerative diseases that affect a high percentage of the population, since oxidative stress and inflammation are common features of these diseases and impact the functions and structures of organs and tissues differently.

As volumes one and two of the Special Issues “Strategies to Counteract Oxidative Stress and Inflammation in Chronic-Degenerative Diseases” have been successful, we will be exploring this issue further in the International Journal of Molecular Sciences (ISSN: 1422-0067, IF: 5.600, and JCR Category Q1). In this third Special Issue, we collect original articles and reviews on this multifaceted topic that still remains largely unexplored, in order to provide support for the development of novel potential therapeutic approaches.

Suggested topics include, but are not limited to, the following:

  • Cellular and molecular mechanisms to counteract oxidative stress and inflammation in aging and chronic diseases;
  • Dietetic strategies for the prevention of chronic diseases;
  • Oxidative stress as a target for interventions;
  • Association of drugs with antioxidant or anti-inflammatory compounds for the therapy of chronic diseases.

Related papers can be found at the following links:

https://www.mdpi.com/journal/ijms/special_issues/chronic_degenerative_diseases.

https://www.mdpi.com/journal/ijms/special_issues/Chronic_Degenerative_Diseases_II.

Dr. Cecilia Prata
Dr. Cristina Angeloni
Dr. Tullia Maraldi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic-degenerative diseases
  • oxidative stress
  • inflammation
  • nutrition
  • nutraceuticals
  • stem cell therapy

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

24 pages, 3534 KiB  
Article
Environmental Enrichment Prevents Gut Dysbiosis Progression and Enhances Glucose Metabolism in High-Fat Diet-Induced Obese Mice
by Rubiceli Manzo, Luigui Gallardo-Becerra, Sol Díaz de León-Guerrero, Tomas Villaseñor, Fernanda Cornejo-Granados, Jonathan Salazar-León, Adrian Ochoa-Leyva, Gustavo Pedraza-Alva and Leonor Pérez-Martínez
Int. J. Mol. Sci. 2024, 25(13), 6904; https://doi.org/10.3390/ijms25136904 - 24 Jun 2024
Cited by 1 | Viewed by 2198
Abstract
Obesity is a global health concern implicated in numerous chronic degenerative diseases, including type 2 diabetes, dyslipidemia, and neurodegenerative disorders. It is characterized by chronic low-grade inflammation, gut microbiota dysbiosis, insulin resistance, glucose intolerance, and lipid metabolism disturbances. Here, we investigated the therapeutic [...] Read more.
Obesity is a global health concern implicated in numerous chronic degenerative diseases, including type 2 diabetes, dyslipidemia, and neurodegenerative disorders. It is characterized by chronic low-grade inflammation, gut microbiota dysbiosis, insulin resistance, glucose intolerance, and lipid metabolism disturbances. Here, we investigated the therapeutic potential of environmental enrichment (EE) to prevent the progression of gut dysbiosis in mice with high-fat diet (HFD)-induced metabolic syndrome. C57BL/6 male mice with obesity and metabolic syndrome, continuously fed with an HFD, were exposed to EE. We analyzed the gut microbiota of the mice by sequencing the 16s rRNA gene at different intervals, including on day 0 and 12 and 24 weeks after EE exposure. Fasting glucose levels, glucose tolerance, insulin resistance, food intake, weight gain, lipid profile, hepatic steatosis, and inflammatory mediators were evaluated in serum, adipose tissue, and the colon. We demonstrate that EE intervention prevents the progression of HFD-induced dysbiosis, reducing taxa associated with metabolic syndrome (Tepidimicrobium, Acidaminobacteraceae, and Fusibacter) while promoting those linked to healthy physiology (Syntrophococcus sucrumutans, Dehalobacterium, Prevotella, and Butyricimonas). Furthermore, EE enhances intestinal barrier integrity, increases mucin-producing goblet cell population, and upregulates Muc2 expression in the colon. These alterations correlate with reduced systemic lipopolysaccharide levels and attenuated colon inflammation, resulting in normalized glucose metabolism, diminished adipose tissue inflammation, reduced liver steatosis, improved lipid profiles, and a significant reduction in body weight gain despite mice’s continued HFD consumption. Our findings highlight EE as a promising anti-inflammatory strategy for managing obesity-related metabolic dysregulation and suggest its potential in developing probiotics targeting EE-modulated microbial taxa. Full article
Show Figures

Graphical abstract

Back to TopTop