Advances in Magnetic Resonance Imaging in Diagnostics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (1 April 2024) | Viewed by 2670
Special Issue Editor
Interests: diagnostic imaging; pediatric radiology; abdomen MR imaging; lunge MR imaging; MR-urography; MRI safety; gadolinium-based contrast agent; radiation protection; computed tomography; diagnostic radiography
Special Issue Information
Dear Colleagues,
Today, magnetic resonance imaging (MRI) with and without gadolinium-based contrast agents (GBCA) is an inseparable tool in the diagnosis and follow-up of patients e.g. after trauma, infections, stroke and oncological diseases, as well as in patients with chronic inflammatory, degenerative or functional disorders, both children and in adults. MRI is an important tool in prenatal diagnostics. In addition to established MRI sequences, new faster sequences are continously being developed, promising shorter scans that reduce the need for sedation in young children and also enable more comfortable scans in adults. Developments in the hybrid PET-MRI improve the treatment of oncological patients. Gadolinium in GBCAs is chelated with organic chelating agents. The toxic side effect of GBCAs due to the release of free Gd3+ ions from the chelating agents and gadolinium deposition in bone, brain and kidneys after repeated use of GBCAs as well as the reported development of nephrogenic systemic fibrosis (NSF) require new strategies to stabilize Gd3+ ions in chelating agents to increase their stability, biocompatibility and pharmacokinetics and thereby improve their safety profile. Bioresponsive GBCAs have the potential to visualize biochemical processes, such as gene expression, neuronal signaling, and hormone secretion. The challenge, to make MRI with bioresponsive GBCAs fit for non-invasive diagnostic and theranostic applications, required collaborations between researchers from chemistry, biology and biomedical engineering as well as clinicians.
As the Guest Editor of this Special Issue, “Advances in Magnetic Resonance Imaging in Diagnostics”, in IJMS, I expect submissions from many researchers working on the wide spectrum of MRI, PET-MRI, moleculare imaging, as well as GBCAs engineering. The focus of this topic is the new MRI tools, new GBCAs, bioresponsive GBCAs and MRI and GBCA safety as well as application of artifificial intenligence (AI). The formats for submissions include original research, reports, reviews, perspectives/opinions and methodology articles.
Dr. Azadeh Hojreh
Guest Editor
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