Research on the Key Role of Ubiquitination in Signaling and Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 August 2026 | Viewed by 805
Special Issue Editor
Special Issue Information
Dear Colleagues,
Ubiquitination plays a pivotal role in regulating key cellular signaling pathways, including those involved in cell proliferation, DNA repair, and apoptosis. By controlling the stability, localization, and activity of critical proteins such as tumor suppressors and oncoproteins, the ubiquitin–proteasome system ensures precise signal transduction and cellular homeostasis. However, dysregulation of ubiquitination—through mutations in E3 ligases, deubiquitinating enzymes, or ubiquitin-binding proteins—can lead to aberrant signaling, the promotion of cancer initiation, progression, and metastasis. Given its central role in oncogenic and tumor-suppressive pathways, understanding the intricate mechanisms of ubiquitination in signaling networks provides critical insights into cancer biology and potential precision medicine approaches. Therefore, in this Special Issue, we will focus on the role of ubiquitination in signal transduction, tumor proliferation and progression, as well as recent advances in drug development and the underlying molecular mechanisms.
Dr. Bo Zhao
Guest Editor
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Keywords
- ubiquitin
- ubiquitination
- E3 ligase
- deubiquitinating enzymes
- protein degradation
- mutations
- cancer progression
- signal transduction
- drug development
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