Roles of Mast Cells in Immune-Induced Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (20 October 2025) | Viewed by 16587
Special Issue Editors
Interests: mast cells; mastocytosis; autoinflammatory disorders; systemic autoimmune disease; allergy
Special Issue Information
Dear Colleagues,
Mast cells are innate-type leukocytes that reside at barrier surfaces of the body, mainly the skin and mucosa, where they contribute to the local immune responses induced by exogenous or physical triggers that disturb local tissue homeostasis. Mast cells are known to expand upon helminth infection. Yet, mast cells can also be found in the organs and tissue of our circulatory and nervous systems.
Different types of activation can be induced. These typically result, in degranulation whereby different kinds of preformed mediators can be rapidly expelled.
Next to the rapid degranulation of preformed molecules, mast cells can initiate a slower pro-inflammatory response. This involves the synthesis and secretion of cytokines and chemokines. These subsequently activate neighbouring cells and recruit and activate infiltrating immune cells. Furthermore, mast cells strongly interact with fibroblasts in wound-healing responses, and mast cell-derived proteases are important in eradicating toxic venoms. All the functional characteristics above illustrate the importance of mast cells in the control of variety of physiological and pathophysiological effects. Mast cells have, for instance, been implicated as playing a role in interstitial lung disease, gastrointestinal disorders and transplant rejection.
In this current Issue of the journal, we aim to illustrate the role of mast cells in various immune-mediated disorders.
Prof. Dr. Paul L.A. Van Daele
Dr. Willem A. Dik
Guest Editors
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Keywords
- mast cell
- fibrosis
- inflammation
- autoinflammation
- autoimmunity
- transplantation
- gastrointestinal
- pulmonary
- cytokines
- MRGPRX2
- rejection
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