Molecular Mechanism of Pathogenesis of Osteoarthritis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3948
Special Issue Editor
Special Issue Information
Dear Colleagues,
Osteoarthritis (OA) occurs not only in knee but also in peripheral joints throughout the whole body. Multiple environmental and genetic factors have been shown to be associated with OA, but the complexity of the joint degradation process is not yet fully understood. Recently, a senescence-inducible factor in cartilage has been reported, and the factor was induced during aging, indicating the existence of key factors which induce degeneration of articular cartilage independent from aging and mechanical loading. In this Special Issue, we invite papers on novel molecular mechanisms of pathogenesis of osteoarthritis, including cell cycle arrest, senescence-promoting molecules, and stem cell senescence.
Dr. Takako Hattori
Guest Editor
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Keywords
- osteoarthritis
- degeneration of cartilage
- mechanical loading
- senescence
- cell cycle
- cellular communication network family member 3 (CCN3)