Unknown Pathogenesis of Musculoskeletal Diseases and Basic Sciences: The Role of New Technologies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 August 2026 | Viewed by 4
Special Issue Editor
Interests: orthopedics; regenerative medicine; hemophilic arthropathy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Musculoskeletal diseases represent a significant burden on global health, yet for many such conditions, the underlying pathogenesis remains elusive. Recent advances in basic sciences—including molecular biology, genetics, immunology, and biomechanics—combined with new technologies offer new perspectives and tools to unravel the complex mechanisms driving these disorders.
We are pleased to invite you to contribute to this Special Issue, which aims to bridge the gap between fundamental research and clinical understanding in musculoskeletal diseases. By focusing on the unknown or poorly understood pathogenic mechanisms, we hope to foster interdisciplinary dialogue and stimulate innovative research that may ultimately lead to improved diagnostics, prevention, and therapies.
Aim:
This Special Issue aims to gather original research and comprehensive reviews that explore the basic science underpinnings of musculoskeletal diseases with unknown or controversial pathogenesis. The goal is to highlight how foundational discoveries can inform clinical practice and open new avenues for translational research.
Scope:
The scope includes, but is not limited to, the following:
- Molecular and cellular mechanisms in musculoskeletal pathology;
- Genetic and epigenetic factors influencing disease onset and progression;
- Immunological and inflammatory pathways;
- Biomechanical and tissue engineering approaches;
- Novel experimental models and methodologies;
- Translational studies linking basic science to clinical outcomes.
We welcome submissions from all relevant disciplines, including biology, medicine, engineering, and computational sciences.
Suggested Themes and Article Types:
- Original research articles;
- Reviews and meta-analyses;
- Methodological papers;
- Case studies with mechanistic insights.
Research areas may include, but are not limited to, the following:
- The use of AI;
- Unraveling molecular pathways in idiopathic musculoskeletal disorders;
- The role of stem cells and regenerative medicine;
- Advances in imaging and biomarker discovery;
- Systems biology and omics approaches;
- Animal models and in vitro systems for pathogenesis studies.
We look forward to receiving your contributions.
Dr. Gianluigi Pasta
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- AI
- musculoskeletal diseases
- pathogenesis
- basic sciences
- molecular mechanisms
- genetics
- immunology
- biomechanics
- translational research
- experimental models
- tissue engineering
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