Predictors of Response to Cancer Immunotherapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 1750
Special Issue Editors
Interests: immunotherapy; genetics; personalized medicine; cancer epidemiology; molecular epidemiology; translational research
Special Issues, Collections and Topics in MDPI journals
Interests: biostatistics; cancer; epidemiology; healthcare; lung; obesity; personalized medicine; public health; thyroid; translational research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immunotherapy has revolutionized cancer treatment and is now the mainstay for advanced non-small-cell lung cancer, melanoma, and other cancers. Yet, while many patients experience dramatic and durable treatment response, others do not benefit from immunotherapy, or they are plagued by extreme, treatment-limiting side effects. Research is ongoing to identify which personal characteristics, biomarkers, and clinical or histological features may explain heterogeneity in immunotherapy effectiveness. Patient’s sex, race, comorbidity, and concurrent medication, as well as histology, specific tumor mutational profile, and tumor immune microenvironment, likely modulate immunotherapy response. For instance, specific gene-expression signatures in immune cells have been demonstrated to predict immunotherapy efficacy. Moreover, research suggests that these factors may behave interactively, either synergistically or antagonistically, to impact immune system response. The availability of reliable predictors of immunotherapy efficacy would have a significant clinical benefit, guiding clinician decision making and improving patient outcomes. Furthermore, profiling-based precision medicine could enable individualized immunotherapy treatment of cancer patients in the future.
This Special Issue is dedicated to understanding predictors, alone or in combination, of immunotherapy efficacy. We warmly welcome submissions, including original papers and reviews, on this critically important topic.
Dr. Stephanie J. Tuminello
Prof. Dr. Emanuela Taioli
Guest Editors
Manuscript Submission Information
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Keywords
- immunotherapy
- immune checkpoint inhibitors
- cancer
- cancer therapy
- precision medicine
- survival outcomes
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