The Role of Phosphatases in Human Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 2966
Special Issue Editor
Interests: endothelial cells; protein phosphatases; protein-protein interaction; cell signaling; lung diseases; angiogenesis; posttranslational modifications
Special Issue Information
Dear Colleagues,
Reversible protein phosphorylation is one of the most common post-translational modifications of proteins that regulates many, if not all, biological processes. Protein kinases attach a phosphate group to a specific side chain of proteins, while protein phosphatases are able to remove it via hydrolysis. The equilibrium between the activities of protein kinases and phosphatases is tightly regulated, ensuring the proper signal transduction of cells.
Abnormal protein phosphorylation, as well as insufficient dephosphorylation of proteins has been shown to cause various diseases such as cancer, neurodegenerative diseases, or immune system-related diseases. Thus, studying protein phosphatases themselves as well as their potential inhibitors or activators is an increasingly well-researched topic. A better understanding of protein dephosphorylation in signaling pathways is crucial in disease research and in therapeutic interventions in clinical trials.
This Special Issue welcomes comprehensive systematic reviews, impactful communications, and full research papers, including basic studies that will provide novel insights into the current knowledge of protein phosphatases in human diseases, while improving the understanding of novel molecular therapeutic applications.
Research topics may include (but are not limited to) the following:
- Correlation between diseases and protein phosphatases;
- Novel signaling mechanism related to phosphorylation;
- Phosphorylation of specific disease-related proteins;
- Therapeutic strategies based on targeting phosphatases or substrate proteins.
Dr. Boratkó Anita
Guest Editor
Manuscript Submission Information
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Keywords
- protein dephosphorylation
- protein phosphatase
- reversible phosphorylation
- phospho-substrate
- human diseases
- cell signaling
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