Molecular Basis and Underlying Mechanisms of Esophageal Cancer Development

Dear Colleagues,

Esophageal cancer (EC) is primarily represented by esophageal squamous carcinoma (ESCC) and esophageal adenocarcinoma (EAC) subtypes, which largely differ in many aspects, including geographic location, etiological factors, and, overall, the molecular alterations that govern the development of these two EC subtypes. Moreover, esophageal cancer is already known to be a highly incident and lethal neoplasia, where late detection and poor prognosis are intimately associated with few emerging therapeutic approaches for this cancer type. In this way, EC still remains poorly impacted by new therapeutic options, a fact that could be associated with the low biological knowledge regarding this tumor. Therefore, the discovery and identification of new molecular targets, as well as the understanding of their role in the development and evolution of EC, may advance current knowledge in this area. In this sense, despite the scientific revolution experienced during the last few years, EC still presents a challenging scenario. Thus, due to the notorious molecular heterogeneity which characterizes EC, this Special Issue aims to focus on recent discoveries of molecular alterations potentially associated not only with EC detection and prognosis, but also with mechanisms involved in the development and treatment of this disease.

Dr. Antônio Palumbo Júnior
Dr. Nathalia de Oliveira Meireles Da Costa
Guest Editors

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• molecular profiling of esophageal cancer
• esophageal cancer prevention and diagnosis
• microenvironment and metastasis of esophageal cancer
• molecular alterations involved in esophageal cancer development and progression
• molecular therapy approaches in esophageal cancer