Hemodynamic Stress and Endothelial Dysfunction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 125
Special Issue Editors
Interests: dental pulp stem cell; tissue regeneration; stem cells; biology; molecular biology; pharmaceutics
Special Issue Information
Dear Colleagues,
Endothelial cells (ECs) play a central role in regulating vascular tone, angiogenesis, wound healing, smooth cell proliferation, fibrosis, and inflammation. Biomechanical stress is a key contributor in the development of several vascular illnesses. Pulsatile blood flow within vessels exposes the vessel wall to various biomechanical stresses, including axial, longitudinal, and shear stress.
Shear stress is influenced by blood velocity, viscosity, and vessel diameter. Pulsatile blood flow subjects the vessel wall to a complex interplay of biomechanical stresses that directly influence vascular remodeling and the onset of disease. Understanding the effects of mechanical stresses on endothelial cells is therefore crucial for understanding the complicated mechanisms behind vascular physiology and the pathogenesis of vascular diseases.
Bioengineered in vitro platforms, including microfluidics, organ-on-a-chip (OoC), and organoids, represent a transformative frontier for modeling complex vascular diseases such as aneurysms. By integrating human cells with precise microscale engineering, these platforms replicate physiological environments far more accurately than traditional 2D cultures or animal models.
This Special Issue aims to investigate how mechanical forces like shear stress and pulse pressure trigger endothelial injury, oxidative stress, and vascular remodeling. Moreover, it aims to evaluate therapeutic implications of endothelial function to establish personalized prevention.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Hemodynamic forces and mechanotransduction;
- Molecular mechanisms of dysfunction;
- Inflammatory and immune responses;
- Vascular diseases and clinical conditions;
- Novel biomarkers and diagnostics;
- Therapeutic and preventive strategies.
We look forward to receiving your contributions.
Dr. Guya Diletta Marconi
Dr. Pamela Mozetic
Guest Editor
Manuscript Submission Information
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Keywords
- hemodynamic stress
- microfluidics
- organ-on-a-chip
- endothelial dysfunction
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