Health Effects of Electronic Nicotine Delivery Systems (ENDS): What Can Be Learned from Human and Experimental Studies?

Dear Colleagues,

Electronic nicotine delivery devices (ENDS), including electronic cigarettes (e-cigs), were introduced to the US market in 2007. Ever since, the ENDS landscape has evolved quickly to satisfy users’ recreational and smoking cessation needs. Currently, over 13 million Americans, including teenagers and adults, use ENDS. In 2019, there was an outbreak of e-cig or vaping-associated lung injury (EVALI) across the U.S., with more than 2,800 cases of lung injury plus 65 associated deaths. EVALI has been diagnosed in patients since 2012 and is observed in nicotine-exclusive ENDS users. Clearly, all ENDS are not “safe”, and more research on vaping health outcomes is urgently needed. The scientific evidence for future regulations related to ENDS products is based on in vitro and in vivo experiments, as well as clinical and epidemiological studies. It is imperative to investigate the potential adverse health effects of ENDS use because of the increasing popularity of ENDS among youths and young adults, some of whom are never-smokers, as well as in dual-users of cigarette and e-cig products. Furthermore, as a result of the rapid evolution of ENDS products, there is a continuing need to evaluate health effects as new products emerge. In addition, there is a paucity of data related to the health effects of inhaled ENDS aerosols, including the effects related to the cardiopulmonary and reproductive systems and second-hand exposure. This Special Issue, entitled: “Health Effects of Electronic Nicotine Delivery Systems (ENDS):What Can Be Learned from Human and Experimental Studies?”, aims to advance this scientific field by providing additional knowledge and bridging the research gap related to the toxicity mechanisms of ENDS products on human health.

Dr. Alexandra Noël
Dr. Meghan Rebuli
Guest Editors

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