Special Issue "Health Effects of Electronic Nicotine Delivery Systems (ENDS): What Can Be Learned from Human and Experimental Studies?"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Alexandra Noël
E-Mail Website
Guest Editor
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA
Interests: inhalation toxicology and developmental toxicology; pulmonary effects of distinct emerging inhaled environmental pollutants, including nanoparticles, second-hand smoke, electronic cigarette aerosols, and hookah smoke
Dr. Meghan Rebuli
E-Mail Website
Guest Editor
Department of Pediatrics, Center for Environmental Medicine, Asthma and Lung Biology and Curriculum in Toxicology & Environmental Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Interests: respiratory toxicology; clinical, ex vivo, and in vitro e-cigarette respiratory immune toxicity and e-cigarette effects on host defense responses to viral infection

Special Issue Information

Dear Colleagues,

Electronic nicotine delivery devices (ENDS), including electronic cigarettes (e-cigs), were introduced to the US market in 2007. Ever since, the ENDS landscape has evolved quickly to satisfy users’ recreational and smoking cessation needs. Currently, over 13 million Americans, including teenagers and adults, use ENDS. In 2019, there was an outbreak of e-cig or vaping-associated lung injury (EVALI) across the U.S., with more than 2,800 cases of lung injury plus 65 associated deaths. EVALI has been diagnosed in patients since 2012 and is observed in nicotine-exclusive ENDS users. Clearly, all ENDS are not “safe”, and more research on vaping health outcomes is urgently needed. The scientific evidence for future regulations related to ENDS products is based on in vitro and in vivo experiments, as well as clinical and epidemiological studies. It is imperative to investigate the potential adverse health effects of ENDS use because of the increasing popularity of ENDS among youths and young adults, some of whom are never-smokers, as well as in dual-users of cigarette and e-cig products. Furthermore, as a result of the rapid evolution of ENDS products, there is a continuing need to evaluate health effects as new products emerge. In addition, there is a paucity of data related to the health effects of inhaled ENDS aerosols, including the effects related to the cardiopulmonary and reproductive systems and second-hand exposure. This Special Issue, entitled: “Health Effects of Electronic Nicotine Delivery Systems (ENDS):What Can Be Learned from Human and Experimental Studies?”, aims to advance this scientific field by providing additional knowledge and bridging the research gap related to the toxicity mechanisms of ENDS products on human health.

Dr. Alexandra Noël
Dr. Meghan Rebuli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • electronic nicotine delivery devices (ENDS)
  • electronic cigarettes
  • e-cigarettes
  • vaping
  • respiratory system
  • cardiovascular system
  • health effects
  • in vivo
  • in vitro
  • epidemiology

Published Papers (1 paper)

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A Descriptive Analysis of Transitions from Smoking to Electronic Nicotine Delivery System (ENDS) Use: A Daily Diary Investigation
Int. J. Environ. Res. Public Health 2021, 18(12), 6301; https://doi.org/10.3390/ijerph18126301 - 10 Jun 2021
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Objectives: We aimed to examine patterns in smoking and electronic nicotine delivery system (ENDS) use over an extended period of time (up to 20 weeks) in people who smoked and who had never previously made a successful quit attempt using an ENDS. Design [...] Read more.
Objectives: We aimed to examine patterns in smoking and electronic nicotine delivery system (ENDS) use over an extended period of time (up to 20 weeks) in people who smoked and who had never previously made a successful quit attempt using an ENDS. Design and setting: We conducted a longitudinal mixed-methods study in Dunedin, New Zealand, during 2018 and 2019. Participants: Purposively selected participants (N = 45; age (≥18 years), gender, ethnicities, cigarettes/day) who wished to quit smoking. Interventions: Participants were provided with a second-generation ENDS device (vape pen or starter “tank” device) at the start of their quit attempt, and asked to complete smartphone-based daily diary surveys assessing smoking and ENDS use. Outcome measures: Sunburst plots and a sequence plot were used to describe weekly and daily patterns of smoking and ENDS use (smoking only, ENDS use only, dual use, abstinent). Results: The most frequently reported movements among participants, classified according to their study week behaviour, occurred between dual use and exclusive ENDS use (and vice versa). A smaller group reported moving from dual use to exclusive smoking (and often back to dual use), and a small number reported moving between abstinence and different ENDS and smoked tobacco usage behaviours. Data visualisations focussing on those participants who had provided data during each of weeks 9–12 indicate that only a minority reported sustained dual use; instead, most participants indicated varied smoked tobacco and ENDS use, which included periods of dual use. Conclusions: The considerable variety observed within and between study participants suggests that high variability is typical rather than exceptional. Transitions from smoking to ENDS use may involve considerable periods of dual use, which is likely to be dynamic and potentially sustained over several months. Full article
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