Physical Activity Might Reduce the Adverse Impacts of the FTO Gene Variant rs3751812 on the Body Mass Index of Adults in Taiwan
1
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan
2
Institute of Clinical Medicine, National Yang-Ming University, Taipei 11221, Taiwan
3
Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Road, Taichung 40201, Taiwan
4
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
5
Department of Psychiatry, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sect. 4, Xitun District, Taichung 407, Taiwan
*
Authors to whom correspondence should be addressed.
Genes 2019, 10(5), 354; https://doi.org/10.3390/genes10050354
Received: 11 April 2019 / Revised: 3 May 2019 / Accepted: 6 May 2019 / Published: 9 May 2019
(This article belongs to the Special Issue Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise)
The fat mass and obesity-associated (FTO) gene is a significant genetic contributor to polygenic obesity. We investigated whether physical activity (PA) modulates the effect of FTO rs3751812 on body mass index (BMI) among Taiwanese adults. Analytic samples included 10,853 Taiwan biobank participants. Association of the single-nucleotide polymorphism (SNP) with BMI was assessed using linear regression models. Physical activity was defined as any kind of exercise lasting 30 min each session, at least three times a week. Participants with heterozygous (TG) and homozygous (TT) genotypes had higher BMI compared to those with wild-type (GG) genotypes. The β value was 0.381(p < 0.0001) for TG individuals and 0.684 (p = 0.0204) for TT individuals. There was a significant dose-response effect among carriers of different risk alleles (p trend <0.0001). Active individuals had lower BMI than their inactive counterparts (β = −0.389, p < 0.0001). Among the active individuals, significant associations were found only with the TG genotype (β = 0.360, p = 0.0032). Inactive individuals with TG and TT genotypes had increased levels of BMI compared to those with GG genotypes: Their β values were 0.381 (p = 0.0021) and 0.950 (p = 0.0188), respectively. There was an interaction between the three genotypes, physical inactivity, and BMI (p trend = 0.0002). Our data indicated that increased BMI owing to genetic susceptibility by FTO rs3751812 may be reduced by physical activity.
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Keywords:
body mass index; Taiwan biobank; obesity; physical exercise
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MDPI and ACS Style
Liaw, Y.-C.; Liaw, Y.-P.; Lan, T.-H. Physical Activity Might Reduce the Adverse Impacts of the FTO Gene Variant rs3751812 on the Body Mass Index of Adults in Taiwan. Genes 2019, 10, 354. https://doi.org/10.3390/genes10050354
AMA Style
Liaw Y-C, Liaw Y-P, Lan T-H. Physical Activity Might Reduce the Adverse Impacts of the FTO Gene Variant rs3751812 on the Body Mass Index of Adults in Taiwan. Genes. 2019; 10(5):354. https://doi.org/10.3390/genes10050354
Chicago/Turabian StyleLiaw, Yi-Ching; Liaw, Yung-Po; Lan, Tsuo-Hung. 2019. "Physical Activity Might Reduce the Adverse Impacts of the FTO Gene Variant rs3751812 on the Body Mass Index of Adults in Taiwan" Genes 10, no. 5: 354. https://doi.org/10.3390/genes10050354
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