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Physical Activity and Brain Health
Open AccessArticle

Genetically Determined Physical Activity and Its Association with Circulating Blood Cells

Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
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Genes 2019, 10(11), 908; https://doi.org/10.3390/genes10110908
Received: 18 September 2019 / Revised: 4 November 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
Lower levels of physical activity (PA) have been associated with increased risk of cardiovascular disease. Worldwide, there is a shift towards a lifestyle with less PA, posing a serious threat to public health. One of the suggested mechanisms behind the association between PA and disease development is through systemic inflammation, in which circulating blood cells play a pivotal role. In this study we investigated the relationship between genetically determined PA and circulating blood cells. We used 68 single nucleotide polymorphisms associated with objectively measured PA levels to perform a Mendelian randomization analysis on circulating blood cells in 222,645 participants of the UK Biobank. For inverse variance fixed effects Mendelian randomization analyses, p < 1.85 × 10−3 (Bonferroni-adjusted p-value of 0.05/27 tests) was considered statistically significant. Genetically determined increased PA was associated with decreased lymphocytes (β = –0.03, SE = 0.008, p = 1.35 × 10−3) and decreased eosinophils (β = –0.008, SE = 0.002, p = 1.36 × 10−3). Although further mechanistic studies are warranted, these findings suggest increased physical activity is associated with an improved inflammatory state with fewer lymphocytes and eosinophils. View Full-Text
Keywords: physical activity; blood cell counts; single nucleotide polymorphisms; inflammation physical activity; blood cell counts; single nucleotide polymorphisms; inflammation
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Prins, F.M.; Said, M.A.; van de Vegte, Y.J.; Verweij, N.; Groot, H.E.; van der Harst, P. Genetically Determined Physical Activity and Its Association with Circulating Blood Cells. Genes 2019, 10, 908.

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