Special Issue "Genetic Influence in Exercise Performance"
Deadline for manuscript submissions: closed (31 July 2020).
Interests: exercise, sport, exercise physiology, physical activity, physical performance, anti-doping, substrate oxidation, ergogenic aids, supplements
Interests: human responses and adaptations to physical exercise; genetic factors; animal models; benefits of exercise interventions in various diseased populations in the hospital
At the start of the new millennium, research in genetics and athletic performance primarily focused on finding genetic variants potentially associated with athletic success in either endurance or more power/speed-oriented sports events. Notably, numerous studies have compared the frequency of polymorphic alleles or genotypes (i.e., usually for a given single nucleotide polymorphism [SNP]) in elite athletes vs. non-athletic populations. Nonetheless, candidate gene studies focusing on a small number of SNPs are often limited by lack of replication and the small effect size of an individual SNP. More recently, the use of genome-wide association studies or whole genome sequencing has been helping us to get deeper insight into how genetic variants might (or not) influence physical performance. Of note, athletic success is likely a polygenic trait, which is to be kept in mind when designing studies.
On the other hand, one of the problems with the practical application of genetics to exercise performance is that commercially available panels are often based on information obtained from elite athletic populations (provided there are strong candidates to be real ‘sports performance genes’, which to date is not the case). This information might not be applicable to less successful athletes or to the general population (notably, to design proper individualized training programs aiming at improving health markers such as cardiorespiratory or muscle fitness). More research is thus needed on the real applicability of knowledge on genetic factors of exercise performance. In addition, a potential confounder when trying to analyze the evidence available is that well-designed studies reporting no association between genotype and exercise-related phenotypes (i.e., ‘negative findings’) are less likely to receive attention or to be published in strongest journals than those showing one or more ‘positive finding’. In this respect, a balanced view of the evidence available is desirable.
As the guest editors of the Special Issue “Genetic Influence in Athletic Performance”, we kindly invite you to submit a manuscript to Genes, one of the most read and cited research journals in the field of Genetics. The goal of this Special Issue is to provide evidence on how genetics might influence athletic performance, by finding new potential candidate gene variants and/or providing strong evidence for an association (or lack of association) of previously studied ones. We are interested in manuscripts that deal with the influence of genetics not only on athletic/exercise performance per se but also on performance-related phenotypes, such as response to exercise training (‘trainability’), risk of muscle-skeletal injury, or muscle tissue characteristics. We welcome original articles, systematic reviews, meta-analyses, or opinions.
Dr. Juan Del Coso
Dr. Alejandro Lucia
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- single nucleotide polymorphism
- exercise performance
- athletic performance
- sport competition
- elite athlete