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Open AccessArticle

Interindividual Variation in Cardiorespiratory Fitness: A Candidate Gene Study in Han Chinese People

1
Institute of Physical Education, Inner Mongolia Normal University, Huhehaote 010022, China
2
Center for Sport Studies, Rey Juan Carlos University, 28943 Fuenlabrada, Spain
3
Sport Science School, Beijing Sport University, Beijing 100083, China
4
Biology Center, China Institute of Sport Science, Beijing 100061, China
5
Faculty of Health Sciences, Universidad Autónoma de Chile, Talca 3460000, Chile
6
Department of Systems Biology, University of Alcalá, 28805 Madrid, Spain
7
Faculty of Sport Sciences, European University of Madrid, 28670 Madrid, Spain
8
Research Institute Hospital 12 de Octubre (‘imas12’), 28041 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Genes 2020, 11(5), 555; https://doi.org/10.3390/genes11050555
Received: 1 April 2020 / Revised: 1 May 2020 / Accepted: 11 May 2020 / Published: 15 May 2020
(This article belongs to the Special Issue Genetic Influence in Exercise Performance)
Cardiorespiratory fitness, as assessed through peak oxygen uptake (VO2peak), is a powerful health indicator. We aimed to evaluate the influence of several candidate causal genetic variants on VO2peak level in untrained Han Chinese people. A total of 1009 participants (566 women; age [mean ± SD] 40 ± 14 years, VO2peak 29.9 ± 7.1 mL/kg/min) performed a maximal incremental cycling test for VO2peak determination. Genomic DNA was extracted from peripheral whole blood, and genotyping analysis was performed on 125 gene variants. Using age, sex, and body mass as covariates, and setting a stringent threshold p-value of 0.0004, only one single nucleotide polymorphism (SNP), located in the gene encoding angiotensin-converting enzyme (rs4295), was associated with VO2peak (β = 0.87; p < 2.9 × 10−4). Stepwise multiple regression analysis identified a panel of three SNPs (rs4295 = 1.1%, angiotensin II receptor type 1 rs275652 = 0.6%, and myostatin rs7570532 = 0.5%) that together accounted for 2.2% (p = 0.0007) of the interindividual variance in VO2peak. Participants carrying six ‘favorable’ alleles had a higher VO2peak (32.3 ± 8.1 mL/kg/min) than those carrying only one favorable allele (24.6 ± 5.2 mL/kg/min, p < 0.0001). In summary, VO2peak at the pre-trained state is partly influenced by several polymorphic variations in candidate genes, but they represent a minor portion of the variance. View Full-Text
Keywords: VO2max; maximal oxygen uptake; single nucleotide polymorphism; genomics; endurance performance VO2max; maximal oxygen uptake; single nucleotide polymorphism; genomics; endurance performance
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MDPI and ACS Style

Gaowa; Del Coso, J.; Gu, Z.; Gerile, W.; Yang, R.; Díaz-Peña, R.; Valenzuela, P.L.; Lucia, A.; He, Z. Interindividual Variation in Cardiorespiratory Fitness: A Candidate Gene Study in Han Chinese People. Genes 2020, 11, 555. https://doi.org/10.3390/genes11050555

AMA Style

Gaowa, Del Coso J, Gu Z, Gerile W, Yang R, Díaz-Peña R, Valenzuela PL, Lucia A, He Z. Interindividual Variation in Cardiorespiratory Fitness: A Candidate Gene Study in Han Chinese People. Genes. 2020; 11(5):555. https://doi.org/10.3390/genes11050555

Chicago/Turabian Style

Gaowa; Del Coso, Juan; Gu, Zhuangzhuang; Gerile, Wuyun; Yang, Rui; Díaz-Peña, Roberto; Valenzuela, Pedro L.; Lucia, Alejandro; He, Zihong. 2020. "Interindividual Variation in Cardiorespiratory Fitness: A Candidate Gene Study in Han Chinese People" Genes 11, no. 5: 555. https://doi.org/10.3390/genes11050555

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