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Special Issue "DNA Damage Responses in Plants"
Deadline for manuscript submissions: closed (31 October 2017).
Prof. Dr. Alma Balestrazzi Website E-Mail
Department of Biology and Biotechnology ‘Lazzaro Spallanzani’, University of Pavia, via Ferrata 9-27100, Pavia, Italy
Interests: molecular and cellular biology; plant biotechnology; cell suspension cultures; seed germination; seed priming; genotoxic stress; DNA repair; tyrosyl-DNA phosphodiesterase
Dr. Mattia Donà Website E-Mail
Gregor Mendel Institute (GMI) Austrian Academy of Science, Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030 Vienna, Austria
Interests: chromatin remodeling; epigenetic modifications; meiotic and somatic recombination; diRNAs; endoreduplication; transposable elements; cell cycle
Maintenance of genome integrity represents a priority for all living organisms that are exposed to genotoxic stress triggered by metabolic by-products and DNA replication stress, as well as environmental chemical pollutants (pesticides, herbicides, heavy metals, ozone) and physical agents (UV and ionizing radiation). Genomic instability results from the accumulation of lesions that cause structural damage to DNA, impairing fundamental cellular processes, such as DNA replication and transcription. DNA damage includes base and sugar modifications, single- and double-strand breaks, DNA-protein cross-links, and abasic sites. Similar to the other eukaryotes, plants have evolved highly conserved, specialized DNA repair pathways (base excision repair, mismatch repair, nucleotide excision repair, and double-strand break repair which comprises both homologous recombination and non-homologous end-joining), targeting the different types of lesions to ensure the integrity of genetic information. However, being sessile organisms, plants are continuously exposed to genotoxic stress and their peculiar photosynthetic activity, localized within chloroplasts, is a constant source of reactive oxygen species and is extremely harmful to lipids, proteins and nucleic acids.
DNA damage response (DDR) is the sum of multiple cellular pathways, triggered on DNA damage detection in order to activate downstream mechanisms allowing the temporary cell cycle arrest and DNA repair. When damage is accumulated above a critical threshold and DNA repair is not able to reverse lesions, cells undergo programmed cell death, avoiding genetic defects that might impair plant development or limit crop performance in terms of seed quality and yields. In this context, DDR systems act as crucial regulators of cell cycle checkpoints, revealing that DNA damage sensing and signaling are strictly linked to growth. DNA lesions contribute to cell aging and there is renewed interest in plant telomere biology in the context of DNA repair and recombination. Plants can also better withstand genotoxic injury by activating endoreduplication mechanisms. Plant genomes host highly conserved DDR components, both regulators and effectors, but there are several plant-specific features of DDR that make this process unique compared to animals.
This Special Issue aims at providing an update of the last findings in basic and applied plant DDR research on model and crop plants investigated in vitro and/or in the field, under abiotic and biotic stress conditions or exposed to specific genotoxins. Original research articles, research notes, and review articles are welcomed.
Manuscripts should address, but are not restricted to the following topics:
- Relevance of microRNAs in DNA damage response
- Molecular mechanisms underlying DNA damage sensing and repair in plants
- The DNA damage response in seeds
- DNA repair in the context of genome editing
- Genotoxic effects of abiotic stress
- High-throughput approaches for the study of the DNA damage response in plants
- The epigenetic components of the DNA damage response
- Plant telomeres
- The plant nucleolus
- The DNA damage response in the context of mutation breeding
- Bioinformatics tools for the study of DNA repair
- Models for investigating DNA repair and mutagenesis mechanisms in plants
- Transcription hubs controlling the DNA damage response
Dr. Alma Balestrazzi
Dr. Susana Araújo
Dr. Mattia Donà
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.