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Genes 2018, 9(1), 36; https://doi.org/10.3390/genes9010036

Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex

1
Institute of Experimental Botany of the Czech Academy of Sciences (IEB), Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 77900 Olomouc-Holice, Czech Republic
2
Max Planck Institute for Plant Breeding Research (MPIPZ), Carl-von-Linné-Weg 10, 50829 Cologne, Germany
*
Author to whom correspondence should be addressed.
Received: 15 November 2017 / Revised: 3 January 2018 / Accepted: 4 January 2018 / Published: 12 January 2018
(This article belongs to the Special Issue DNA Damage Responses in Plants)
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Abstract

Chromosome organization, dynamics and stability are required for successful passage through cellular generations and transmission of genetic information to offspring. The key components involved are Structural maintenance of chromosomes (SMC) complexes. Cohesin complex ensures proper chromatid alignment, condensin complex chromosome condensation and the SMC5/6 complex is specialized in the maintenance of genome stability. Here we summarize recent knowledge on the composition and molecular functions of SMC5/6 complex. SMC5/6 complex was originally identified based on the sensitivity of its mutants to genotoxic stress but there is increasing number of studies demonstrating its roles in the control of DNA replication, sister chromatid resolution and genomic location-dependent promotion or suppression of homologous recombination. Some of these functions appear to be due to a very dynamic interaction with cohesin or other repair complexes. Studies in Arabidopsis indicate that, besides its canonical function in repair of damaged DNA, the SMC5/6 complex plays important roles in regulating plant development, abiotic stress responses, suppression of autoimmune responses and sexual reproduction. View Full-Text
Keywords: SMC5/6; genome stability; DNA damage repair; Structural maintenance of chromosomes; chromatin; chromosomes SMC5/6; genome stability; DNA damage repair; Structural maintenance of chromosomes; chromatin; chromosomes
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Diaz, M.; Pecinka, A. Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex. Genes 2018, 9, 36.

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