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Volume 8
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10.3390/genes8110331
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Article

Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress

by
Radka Vágnerová
1,
Alena Lukešová
2,
Martin Lukeš
3,
Petra Rožnovská
1,
Marcela Holá
1,
Jana Fulnečková
4,
Jiří Fajkus
5,6 and
Karel J. Angelis
1,*
1
Institute of Experimental Botany, Czech Academy of Sciences, v.v.i., Na Karlovce 1, 16000 Prague 6, Czech Republic
2
Biology Centre ASCR, v.v.i., Institute of Soil Biology, Na Sádkach 7, 37005 České Budějovice, Czech Republic
3
Institute of Microbiology ASCR, Centrum Algatech, Laboratory of photosynthesis, Opatovický mlýn, 379 81 Třeboň, Czech Republic
4
Institute of Biophysics, Czech Academy of Sciences, v.v.i., Královopolská 135, 61265 Brno, Czech Republic
5
Laboratory of Functional Genomics and Proteomics, NCBR, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czech Republic
6
Mendel Centre for Plant Genomics and Proteomics, CEITEC—Central European Institute of Technology, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Genes 2017, 8(11), 331; https://doi.org/10.3390/genes8110331
Submission received: 31 August 2017 / Revised: 10 November 2017 / Accepted: 14 November 2017 / Published: 17 November 2017
(This article belongs to the Special Issue DNA Damage Responses in Plants)
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Abstract

Research in algae usually focuses on the description and characterization of morpho—and phenotype as a result of adaptation to a particular habitat and its conditions. To better understand the evolution of lineages we characterized responses of filamentous streptophyte green algae of the genera Klebsormidium and Zygnema, and of a land plant—the moss Physcomitrella patens—to genotoxic stress that might be relevant to their environment. We studied the induction and repair of DNA double strand breaks (DSBs) elicited by the radiomimetic drug bleomycin, DNA single strand breaks (SSB) as consequence of base modification by the alkylation agent methyl methanesulfonate (MMS) and of ultra violet (UV)-induced photo-dimers, because the mode of action of these three genotoxic agents is well understood. We show that the Klebsormidium and Physcomitrella are similarly sensitive to introduced DNA lesions and have similar rates of DSBs repair. In contrast, less DNA damage and higher repair rate of DSBs was detected in Zygnema, suggesting different mechanisms of maintaining genome integrity in response to genotoxic stress. Nevertheless, contrary to fewer detected lesions is Zygnema more sensitive to genotoxic treatment than Klebsormidium and Physcomitrella
Keywords: Physcomitrella patens; Klebsormidium; Zygnema; DNA damage and repair; bleomycin; methyl methanesulfonate; ultraviolet light Physcomitrella patens; Klebsormidium; Zygnema; DNA damage and repair; bleomycin; methyl methanesulfonate; ultraviolet light

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MDPI and ACS Style

Vágnerová, R.; Lukešová, A.; Lukeš, M.; Rožnovská, P.; Holá, M.; Fulnečková, J.; Fajkus, J.; Angelis, K.J. Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress. Genes 2017, 8, 331. https://doi.org/10.3390/genes8110331

AMA Style

Vágnerová R, Lukešová A, Lukeš M, Rožnovská P, Holá M, Fulnečková J, Fajkus J, Angelis KJ. Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress. Genes. 2017; 8(11):331. https://doi.org/10.3390/genes8110331

Chicago/Turabian Style

Vágnerová, Radka, Alena Lukešová, Martin Lukeš, Petra Rožnovská, Marcela Holá, Jana Fulnečková, Jiří Fajkus, and Karel J. Angelis. 2017. "Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress" Genes 8, no. 11: 331. https://doi.org/10.3390/genes8110331

APA Style

Vágnerová, R., Lukešová, A., Lukeš, M., Rožnovská, P., Holá, M., Fulnečková, J., Fajkus, J., & Angelis, K. J. (2017). Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress. Genes, 8(11), 331. https://doi.org/10.3390/genes8110331

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