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Fluids
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Advances in Hemodynamics and Related Biological Flows, 2nd Edition
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Advances in Hemodynamics and Related Biological Flows, 2nd Edition

A special issue of Fluids (ISSN 2311-5521). This special issue belongs to the section "Non-Newtonian and Complex Fluids".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 749

Special Issue Editors

Prof. Dr. Dimitrios V. Papavassiliou

E-Mail Website
Guest Editor
School of Chemical, Biological, and Materials Engineering, The University of Oklahoma, Norman, OK 73019, USA
Interests: hemodynamics; nanofluidics; computational transport; turbulent transport; flow and transport in porous media
Special Issues, Collections and Topics in MDPI journals
Dr. Mesude Avci

E-Mail Website
Guest Editor
Department of Chemical Engineering, Cumhuriyet University, Sivas 58140, Turkey
Interests: CFD simulations; artificial organs; ventricular assist devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The heart and broad-branched vessel system contains blood, the primary objective of which is to transport substances to and from tissues, prevent fluid loss, and defend the body, constituting the circulatory system. Investigating and understanding the dynamics of blood flow (hemodynamics) and the fluid flow phenomena integral to related biological flows can improve the design and performance of cardiovascular prosthetic devices and the treatment of cardiovascular disease.

This Special Issue will focus on the latest advances made to understand the physics of blood flow through analytical, experimental, and computational studies of hemodynamics. Submissions containing recent advances in hemolysis, both cell-level and molecular-level treatments of hemodynamics, as well as computations of fluid–structure interactions, are welcome. Both fundamental and applied research, such as medical devices with hemodynamics critical to the design process, can be included in manuscripts. Moreover, manuscripts focusing on other biological flow dynamics are also encouraged.

Prof. Dr. Dimitrios V. Papavassiliou
Dr. Mesude Avci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fluids is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biological flow
  • hemodynamics
  • analytical
  • computational
  • experimental
  • blood
  • fluid dynamics
  • computational fluid dynamics
  • red blood cell trauma
  • hemolysis
  • FDA
  • turbulence
  • Kolmogorov length scale
  • erythrocyte
  • artificial organs
  • blood flow
  • pressure loss coefficient
  • developmental biology
  • viscous stress
  • Reynolds stress
  • power law model
  • prosthetic heart devices
  • heart assist devices
  • erythrocyte deformability
  • red blood cell(RBC)
  • mechanical trauma
  • sublethal damage
  • mechanical trauma

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Published Papers (1 paper)

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Research

23 pages, 28834 KB  
Article
Patient-Specific Computational Hemodynamic Modeling of the Right Pulmonary Artery Using CardioMEMS Data: Validation, Simplification, and Sensitivity Analysis
by Angélica Casero, Laura G. Sánchez, Felicia Alfano, Pedro Navas, Juan F. Oteo, Carlos Arellano-Serrano and Manuel Gómez-Bueno
Fluids 2026, 11(3), 83; https://doi.org/10.3390/fluids11030083 - 19 Mar 2026
Viewed by 495
Abstract
This study investigates the application of computational hemodynamic modeling, involving both FSI and CFD models, using SimVascular to simulate blood flow in the right pulmonary artery for patient-specific cardiovascular assessment. The artery’s three-dimensional geometry was reconstructed from a computed tomography (CT) image, and [...] Read more.
This study investigates the application of computational hemodynamic modeling, involving both FSI and CFD models, using SimVascular to simulate blood flow in the right pulmonary artery for patient-specific cardiovascular assessment. The artery’s three-dimensional geometry was reconstructed from a computed tomography (CT) image, and pressure measurements from a CardioMEMS™ device were used as clinical ground truth for validation. To represent the arterial hemodynamics, we initially formulated a fluid–structure interaction (FSI) approach to capture wall mechanics. However, given the high computational cost of fully patient-specific FSI simulations for routine clinical decision-making, we evaluated the validity of key simplifications by assuming rigid vessel walls coupled with a three-element Windkessel (3WK) model and applying a half-sine inflow waveform derived from the patient’s cardiac output. These simplifications yielded results with minimal error: the rigid-wall assumption introduced a 1.1% deviation, while the idealized waveform resulted in a 0.56 mmHg offset. Crucially, while wall rigidity was acceptable, we found that arterial compliance in the boundary conditions is non-negotiable; reducing the model to a pure resistance approach resulted in non-physiological pressures (130 mmHg). A subsequent parametric analysis examined how varying resistance (R) and compliance (C) distinctively alter the pressure waveform morphology. The results underscore the potential of combining remote monitoring data with validated computational simulations to deepen the understanding of cardiovascular dynamics and enhance diagnostic and therapeutic approaches for cardiovascular diseases. Full article
(This article belongs to the Special Issue Advances in Hemodynamics and Related Biological Flows, 2nd Edition)
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