Genetic Breeding and Immunity of Aquatic Animals

A special issue of Fishes (ISSN 2410-3888). This special issue belongs to the section "Genetics and Biotechnology".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 801

Special Issue Editors


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Guest Editor
College of Fisheries, Guangdong Ocean University, Zhanjiang 524088, China
Interests: genetic breeding; aquatic animal immunology; genetic architecture of growth traits

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Guest Editor
College of Marine Sciences, Beibu Gulf University, Qinzhou, China
Interests: innate immunity in fish; mechanism of pathogenic microorganisms
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Guest Editor
Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang 524006, China
Interests: aquatic animal physiology; genetic breeding; temperature adaptation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
School of Life Sciences, Guangzhou University, Guangzhou 510006, China
Interests: genetic breeding; sex determination and control mechanisms in fish

Special Issue Information

Dear Colleagues,

Aquaculture—the farming of aquatic organisms—plays a critical role in global food security, economic development, and environmental sustainability. As the aquaculture industry continues to expand, it faces pressing challenges, including disease outbreaks, environmental stress, and the need for enhanced productivity. In this context, the fields of genetic breeding and immunology have become increasingly vital. Genetic breeding enables the development of improved aquatic animal strains with superior growth performance, disease resistance, and adaptability to changing environments. Research in immunology deepens our understanding of aquatic immune systems, contributing to breeding for disease resistance, enabling the creation of more effective disease prevention and control strategies. Together, these disciplines are fundamental to ensuring the long-term sustainability and resilience of aquaculture.

The aim of this Special Issue is to highlight recent advances and emerging breakthroughs in the genetic breeding and immunity of aquatic animals. We aim to compile cutting-edge research on genomic selection, gene editing technologies, sex control breeding, and marker-assisted selection, as well as fundamental studies elucidating the genetic basis of economically important traits. In addition, we welcome contributions exploring novel immune mechanisms in aquatic species, strategies for enhancing disease resistance, and nutritional immunology areas that are pivotal for advancing sustainable aquaculture. We invite the submission of original research articles, reviews, and methodological papers that expand developments in genetic and immunological applications in aquaculture, with the goal of promoting scientific exchange and driving innovation in the field.

Dr. Zhe Zheng
Dr. Xiaohui Cai
Dr. Ruijuan Hao
Guest Editors

Dr. Jin-lian Liang
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fishes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetic breeding
  • aquatic animal immunity
  • disease resistance
  • genomic selection
  • gene editing

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Published Papers (1 paper)

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Research

21 pages, 3665 KB  
Article
β,β-Dimethylacrylshikonin Alleviates Zebrafish (Danio rerio) Soyasaponin-Induced Enteritis by Maintaining Intestinal Homeostasis and Improving Intestinal Immunity and Metabolism
by Ming Liu, Xin Lu, Leong-Seng Lim, Yinhui Peng, Lulu Liu, Kianann Tan, Peng Xu, Mingzhong Liang, Yingrui Wu, Qingfang Gong and Xiaohui Cai
Fishes 2025, 10(11), 567; https://doi.org/10.3390/fishes10110567 - 6 Nov 2025
Viewed by 457
Abstract
Soyasaponin intolerance is common in ancient fish species, making them susceptible to enteritis caused by dietary soybean meal. β,β-Dimethylacrylshikonin is the key active monomer found in Lithospermum erythrorhizon and is known for its multiple pharmacological activities. However, its effect on soybean meal-induced enteritis [...] Read more.
Soyasaponin intolerance is common in ancient fish species, making them susceptible to enteritis caused by dietary soybean meal. β,β-Dimethylacrylshikonin is the key active monomer found in Lithospermum erythrorhizon and is known for its multiple pharmacological activities. However, its effect on soybean meal-induced enteritis remains unknown. The administration of 2 g/kg of β,β-Dimethylacrylshikonin (LE) effectively alleviated 5 g/kg of soyasaponin-induced histopathological changes and dysfunction, as evidenced by the expression of inflammation-related genes (il-1β, il-8, and il10). Regarding the gut microbiota composition, LE therapy decreased the population of inflammation-linked Proteobacteria and concurrently elevated the proportion of Fusobacteriota, effectively sustaining the balance of the zebrafish gut microbiota. Moreover, at the genus level, LE treatment also increased the abundance of Cetobacterium. Transcriptional results suggested that LE intervention mainly regulated immune-related pathways, including cytokine–cytokine receptor interaction, the TGF-beta signaling pathway, taurine and hypotaurine metabolism, and arachidonic acid metabolism. In conclusion, 5 g/kg of soyasaponins caused intestinal injury in zebrafish, and β,β-Dimethylacrylshikonin can reduce intestinal inflammation by regulating the intestinal microbial balance and metabolic disorder, with the best effect at 2 g/kg. Full article
(This article belongs to the Special Issue Genetic Breeding and Immunity of Aquatic Animals)
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