Special Issue "Epigenetics of Pancreatic Cancer"
A special issue of Epigenomes (ISSN 2075-4655).
Deadline for manuscript submissions: closed (15 May 2018)
Dr. Christopher Pin
Division Head and Scientist, Genetics and Development, Children's Health Research Institute Associate Professor, Depts. of Paediatrics, Physiology and Pharmacology, and Oncology Schulich School of Medicine and Dentistry, University of Western Ontario
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Interests: epigenetic regulation of pancreatic development and disease; acinar-to-duct cell metaplasia; unfolded protein response; ER stress; acinar cell physiology
This Special Issue focuses on the role of epigenetics in pancreatic cancer, a dismal disease predicted to be second cause of cancer death by 2030. This aggressive and rapidly-disseminated epithelial neoplasm is highly resistant to conventional chemotherapeutic and radiation-based treatments. The past several decades of pancreatic cancer research have yielded a tremendous amount of knowledge about the genetics of tumor cells; however, this knowledge has not translated into significant clinical advances in treatment and prevention. These genetic-based drivers of pancreatic cancer have been well studied, but they do not account for all of the phenotypic and molecular alterations demonstrated by tumor cells. Pancreatic cancer initiation and progression is the result of a heterogeneous and dynamic combination of both genetic and epigenetic mechanisms. With the identification of epigenetic alterations seen in early pancreatic preneoplastic lesions through the development of pancreatic cancer, there implies an inherent complexity in epigenetic changes that occurs in parallel to genetic changes. This Special Issue will discuss on the present knowledge in field pancreatic cancer epigenetics and will be composed of the following works (see planned papers)
Dr. Martin E. Fernandez-Zapico
Dr. Christopher Pin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) is waived for well-prepared manuscripts submitted to this issue. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- pancreatic cancer
- chromatin dynamics