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Epigenomes 2019, 3(1), 5; https://doi.org/10.3390/epigenomes3010005

Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies

1
Department of Biological Sciences, North Dakota State University, Fargo, ND 58102, USA
2
Department of Public Health, North Dakota State University, Fargo, ND 58102, USA
3
Biostatistics Core Facility, North Dakota State University, Fargo, ND 58102, USA
4
Center for Immunization Research and Education, North Dakota State University, Fargo, ND 58102, USA
5
Genomics and Bioinformatics Program, North Dakota State University, Fargo, ND 58102, USA
*
Author to whom correspondence should be addressed.
Received: 21 December 2018 / Revised: 11 January 2019 / Accepted: 14 January 2019 / Published: 19 January 2019
(This article belongs to the Special Issue Epigenetics of Pancreatic Cancer)
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Abstract

Several challenges present themselves when discussing current approaches to the prevention or treatment of pancreatic cancer. Up to 45% of the risk of pancreatic cancer is attributed to unknown causes, making effective prevention programs difficult to design. The most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is generally diagnosed at a late stage, leading to a poor prognosis and 5-year survival estimate. PDAC tumors are heterogeneous, leading to many identified cell subtypes within one patient’s primary tumor. This explains why there is a high frequency of tumors that are resistant to standard treatments, leading to high relapse rates. This review will discuss how epigenetic technologies and epigenome-wide association studies have been used to address some of these challenges and the future promises these approaches hold. View Full-Text
Keywords: epigenetics; epigenomes; pancreatic cancer; methylation; histones; RNA; DNA; expression epigenetics; epigenomes; pancreatic cancer; methylation; histones; RNA; DNA; expression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Singh, R.R.; Reindl, K.M.; Jansen, R.J. Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies. Epigenomes 2019, 3, 5.

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