Epigenetics of Pancreatic Cancer 2.0

Dear Colleagues,

This Special Issue focuses on the role of epigenetics in pancreatic cancer, a dismal disease predicted to be second cause of cancer death by 2030. This aggressive and rapidly disseminated epithelial neoplasm is highly resistant to conventional chemotherapeutic and radiation-based treatments. The past several decades of pancreatic cancer research have yielded a tremendous amount of knowledge about the genetics of tumor cells; however, this knowledge has not translated into significant clinical advances in treatment and prevention. These genetic-based drivers of pancreatic cancer have been well studied in the past three decades, but they do not account for all of the phenotypic and molecular alterations demonstrated by tumor cells. Pancreatic cancer initiation and progression are the result of a heterogeneous and dynamic combination of both genetic and epigenetic mechanisms. With the identification of epigenetic alterations seen in early pancreatic preneoplastic lesions through the development of pancreatic cancer, an inherent complexity is implied in epigenetic changes that occur in parallel to genetic alterations. This Special Issue will discuss the present knowledge in the field of pancreatic cancer epigenetics and will be composed of the following works:

(see published papers, planned papers, and the publication in the previous Special Issue "Epigenetics of Pancreatic Cancer")

Dr. Martin E. Fernandez-Zapico
Dr. Christopher Pin
Guest Editors

Manuscript Submission Information

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