Artificial Intelligence and Machine Learning for Medical Image Processing

A special issue of Electronics (ISSN 2079-9292). This special issue belongs to the section "Bioelectronics".

Deadline for manuscript submissions: 15 February 2026 | Viewed by 772

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Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
Interests: medical image analysis; machine learning; computer aided skin diagnostics; treatment evaluation
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Special Issue Information

Dear Colleagues,

Artificial intelligence (AI) and machine learning (ML) have become transformative tools in medical image processing, offering innovative solutions to longstanding challenges in clinical diagnostics, treatment planning, and disease monitoring. In response to the exponential growth of medical imaging data and the increasing demand for precision medicine, this Special Issue will bring together cutting-edge research that leverages AI and ML techniques to enhance the interpretation, analysis, and utility of medical images across a wide range of applications.

This Special Issue welcomes original research and comprehensive review articles that explore the integration of AI methodologies with medical imaging. We encourage submissions addressing a wide range of tasks, including segmentation, classification, detection, synthesis, and registration. All types of medical imaging modalities are welcome, including but not limited to MRI, CT, ultrasound, PET, dermatoscopy, endoscopy, and X-ray imaging.

We particularly encourage submissions that propose novel machine learning models, efficient training strategies, interpretable AI solutions, and/or robust validation pipelines. Papers addressing real-world clinical applications, data-driven discovery, and system-level integration of AI into medical workflows are also welcome.

We invite researchers to contribute their most recent findings to this Special Issue, helping to shape the future of AI-driven medical image processing.

Dr. Panagiota Spyridonos
Guest Editor

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Keywords

  • artificial intelligence
  • machine learning
  • medical image processing
  • deep learning
  • medical image segmentation
  • classification
  • detection
  • transformer networks
  • convolutional neural networks (CNNs)
  • medical imaging modalities (MRI, CT, X-ray, Ultrasound, PET)
  • computer-aided diagnosis (CAD)

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Published Papers (1 paper)

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Research

17 pages, 2143 KB  
Article
Application of StarDist to Diagnostic-Grade White Blood Cells Segmentation in Whole Slide Images
by Julius Bamwenda, Mehmet Siraç Özerdem, Orhan Ayyildiz and Veysi Akpolat
Electronics 2025, 14(17), 3538; https://doi.org/10.3390/electronics14173538 - 4 Sep 2025
Viewed by 555
Abstract
Accurate and automated segmentation of white blood cells (WBCs) in whole slide images (WSIs) is a critical step in computational pathology. This study presents a comprehensive evaluation and enhancement of the StarDist algorithm, leveraging its star-convex polygonal modeling to improve segmentation precision in [...] Read more.
Accurate and automated segmentation of white blood cells (WBCs) in whole slide images (WSIs) is a critical step in computational pathology. This study presents a comprehensive evaluation and enhancement of the StarDist algorithm, leveraging its star-convex polygonal modeling to improve segmentation precision in complex WSI datasets. Our pipeline integrates tailored preprocessing, expert annotations from QuPath, and adaptive learning strategies for model training. Comparative analysis with U-Net and Mask R-CNN demonstrates StarDist’s superiority across multiple performance metrics, including Dice coefficient (0.89), precision (0.99), and IoU (0.95). Visual evaluations further highlight its robustness in handling overlapping cells and staining inconsistencies. The study establishes StarDist as a reliable tool for digital pathology, with potential integration into clinical decision-support systems. In addition to Dice and IoU, metrics such as Aggregated Jaccard Index and Boundary F1-Score are gaining popularity for biomedical segmentation. Preprocessing techniques like Macenko stain normalization and adaptive histogram equalization can further improve generalizability. QuPath, an open-source digital pathology platform, was utilized to perform accurate WBC annotations prior to training and evaluation. Full article
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