Advances in Diagnosis and Management of Liver Tumors

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 645

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Guest Editor
Institute of Physics, University of Belgrade, Belgrade, Serbia
Interests: liver tumor; microwave ablation; hepatic microwave ablation
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Special Issue Information

Dear Colleagues,

Liver tumors, including primary malignancies like hepatocellular carcinoma (HCC) and metastatic lesions, pose significant challenges in clinical practice. The rising global incidence of liver cancer underscores the urgent need for enhanced understanding of its diagnosis and management. Recent advancements have markedly improved patient outcomes, making this an exciting time for research and clinical application.

This Special Issue aims to highlight groundbreaking developments in liver tumor diagnosis. Enhanced imaging modalities, such as high-resolution MRI and advanced CT scans, have vastly improved early detection accuracy, enabling timely interventions that can be life-saving. The discovery of novel biomarkers is also transforming screening strategies, facilitating personalized approaches that allow for earlier diagnosis and improved prognostication. Additionally, the integration of artificial intelligence (AI) and machine learning in imaging analysis is revolutionizing diagnostics, allowing for more precise identification and characterization of tumors.

In terms of management, we will explore innovative therapeutic strategies. Targeted therapies that focus on specific molecular pathways have shown promise in inhibiting tumor growth. The advent of immunotherapy, which leverages the body’s immune response to combat cancer, represents a significant breakthrough in treatment options. Furthermore, advancements in minimally invasive surgical techniques—such as laparoscopic and robotic surgeries—are transforming surgical management, resulting in reduced morbidity and faster recovery for patients.

Contributions from leading experts will provide a comprehensive overview of these advancements, emphasizing ongoing research and future directions. By fostering collaboration between researchers and clinicians, we aim to equip healthcare professionals with essential knowledge and resources to improve the diagnosis and management of liver tumors.

We invite authors to submit their research, reviews, and case studies that contribute to this dynamic field. Together, we can address the challenges posed by liver tumors and enhance patient care, driving progress in this critical area of oncology.

Dr. Marija Radmilović-Radjenović
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Keywords

  • liver tumors
  • hepatocellular carcinoma
  • immunotherapy
  • imaging
  • oncology

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Published Papers (1 paper)

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Research

14 pages, 901 KB  
Article
Effect of Lymphatic Invasion on Survival and Recurrence After Liver Transplantation in Patients with Hepatocellular Carcinoma and Its Prognostic Significance
by Umut Tüysüz, İmam Bakır Batı and Tonguc Utku Yılmaz
Diagnostics 2026, 16(5), 741; https://doi.org/10.3390/diagnostics16050741 - 2 Mar 2026
Viewed by 373
Abstract
Objective: An important characteristic of Hepatocellular carcinoma (HCC) is that it features multicentric recurrences that can recur after curative treatment. Current recommended curative treatments for HCC include liver transplantation (LT), and prognostic evaluation and appropriate treatment selection are crucial in the management of [...] Read more.
Objective: An important characteristic of Hepatocellular carcinoma (HCC) is that it features multicentric recurrences that can recur after curative treatment. Current recommended curative treatments for HCC include liver transplantation (LT), and prognostic evaluation and appropriate treatment selection are crucial in the management of HCC patients. Factors considered tend to include tumor size and number, lobar distribution, multinodularity, α-fetoprotein (AFP) level, degree of tumor differentiation, vascular invasion, and satellite nodules. However, the prognostic value of intrahepatic lymphatic vessel invasion (LVI) has rarely been reported for liver cancers. Methods: From January 2012 to December 2020, a total of 178 HCC patients who underwent liver transplantation consecutively were retrospectively enrolled. Those who underwent liver transplantation were divided into two groups based on the presence or absence of lymphatic vessel invasion. The primary aim was to compare the two groups for overall survival (OS), disease free survival (DFS), and recurrence rates, as well as to evaluate the prognostic effect of LVI after transplantation. Results: Poor tumor characteristics such as high tumor differentiation grade and MVI were significantly higher in the patient group with LI. Tumor recurrence and mortality rates were significantly higher in LI-positive recipients. Conclusions: The lymphatic invasion (LI) group displayed higher rates of recurrence and mortality. The findings emphasize the need to incorporate LI assessment into prognostic evaluations to enhance the management and outcomes of individuals with Hepatocellular carcinoma. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Management of Liver Tumors)
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