Diagnostic and Management of Acquired Hemophilia

Dear Colleagues, 

Acquired hemophilia A is a rare bleeding disorder caused by a spontaneous development of autoantibodies against the coagulation factor VIII in males and females with a previously normal hemostasis.

Morbidity and mortality associated with AHA are high, especially in elderly patients with severe co-morbidities.

The use of hemostatic agents to control bleeding and immunosuppressive therapy to eliminate the inhibitor are the gold standard of the treatment.

Hemostatic therapy regimens involve recombinant activated factor VII (rVIIa) and/or activated prothrombin concentrate complex (aPCC) and, more recently, recombinant porcine FVIII (rpFVIII), but it is not clear how they should be chosen to obtain the best control of bleeding.

Steroids, cyclophosphamide, or rituximab are used as immunosuppressive therapy; therefore, it would be important to use these drugs alone or combined in different ways depending on the cause of acquired hemophilia.

Laboratory diagnosis can be complicated, and several limitations and pitfalls exist in the assays used to diagnose AHA.

This Special Issue in “Diagnostic and Management of Acquired Hemophilia” aims to provide an overview of current laboratory diagnosis and strategy of treatment.

Full research papers, communications, and review articles are welcome to give answers to the many questions and concerns related to this field.

Dr. Ezio Zanon
Guest Editor

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