Multimodal Optical Diagnostics of Glycated Biological Tissues

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Optical Diagnostics".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 3238

Special Issue Editor

E-Mail Website
Guest Editor
Aston Institute of Photonic Technologies, Aston University, Birmingham, UK
Interests: biomedical imaging; biophotonics; biomedical engineering; Monte Carlo simulation; laser optics; applied optics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of diabetes complications is a significant public health problem with a considerable economic cost. Over the past few years, the prevalence of diabetes has reached alarmingly high levels. The number of patients diagnosed with this disease already amounts to approximately half a billion worldwide, and this number will only grow in the near future, according to forecasts. Thus, the timely diagnosis of complications and the prevention of their development will contribute to increasing the length and quality of patients lives, as well as reducing the economic costs of their treatments.

Light-based technologies present unique opportunities for the diagnosis of various pathological disorders of biological tissues. Various spectroscopy and imaging technologies can provide information on their optical properties, which are directly related to its blood supply, degree of oxygenation, and the morphological changes.

This Special Issue will highlight the advantages and unique aspects of the use of optical diagnostic methods in identifying and evaluating complications of diabetes. Articles may focus on the application of technology, disease, or other aspects of the use of spectroscopy and imaging in clinical practice. Articles should reflect novel innovative research and emerging ideas. 

Dr. Viktor Dremin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • glycation 
  • diabetes mellitus
  • biomedical photonics 
  • multimodal optical diagnostics 
  • spectroscopy 
  • optical imaging

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


15 pages, 2655 KiB  
Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin
by Carolina Bernal-Morales, Aníbal Alé-Chilet, Ruben Martín-Pinardel, Marina Barraso, Teresa Hernández, Cristian Oliva, Irene Vinagre, Emilio Ortega, Marc Figueras-Roca, Anna Sala-Puigdollers, Marga Gimenez, Enric Esmatjes, Alfredo Adán and Javier Zarranz-Ventura
Diagnostics 2021, 11(9), 1537; - 25 Aug 2021
Cited by 6 | Viewed by 2469
The purpose of this study was to evaluate specifically the relationship between glycated haemoglobin (HbA1c) levels and retinal optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in type 1 Diabetes Mellitus (DM). A total of 478 type 1 DM patients and 115 [...] Read more.
The purpose of this study was to evaluate specifically the relationship between glycated haemoglobin (HbA1c) levels and retinal optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in type 1 Diabetes Mellitus (DM). A total of 478 type 1 DM patients and 115 controls were included in a prospective OCTA trial ( NCT03422965). Subgroup analysis was performed for controls, no diabetic retinopathy (DM-no DR) and DR patients (DM-DR), and HbA1c levels. OCT and OCTA measurements were compared with HbA1c levels (current and previous 5 years). DM-no DR patients with HbA1c levels >7.5% showed lower VD than DM-DR and controls (20.16 vs. 20.22 vs. 20.71, p < 0.05), and showed a significant correlation between HbA1c levels and FAZc (p = 0.04), after adjusting for age, gender, signal strength index, axial length, and DM disease duration. DM-DR patients with HbA1c > 7.5% presented greater CRT than DM-no DR and controls (270.8 vs. 260 vs. 251.1, p < 0.05) and showed a significant correlation between HbA1c and CRT (p = 0.03). In conclusion, greater levels of HbA1c are associated with OCTA changes in DM-no DR patients, and with structural OCT changes in DM-DR patients. The combination of OCTA and OCT measurements and HbA1c levels may be helpful to identify patients at risk of progression to greater stages of the diabetic microvascular disease. Full article
(This article belongs to the Special Issue Multimodal Optical Diagnostics of Glycated Biological Tissues)
Show Figures

Figure 1

Back to TopTop