New Horizons in Multiple Myeloma Diagnosis and Therapy

Dear Colleagues,

Multiple myeloma is a complex disease which often requires a multidisciplinary approach in diagnostics and therapy. Significant advancements have been achieved in recent years. New imaging techniques offer greater sensitivity in detecting bone lesions early on and assessing bone marrow involvement as well as extramedullary disease. Novel biomarkers improve diagnostic accuracy, while genetic and epigenomic profiling provides deeper insights into disease progression. Artificial intelligence and machine learning are also being developed to analyze complex genomic and clinical data, enabling more precise risk stratification and decision-making. Recent advances in multiple myeloma therapy include new quadruplet drug combinations for frontline treatment, as well as the approval and expansion of CAR T-cell therapies and bispecific antibodies. These innovations will lead to deeper and longer-lasting remissions, improving patient outcomes and transforming the prognosis for multiple myeloma patients. Improved supportive care concepts for myeloma patients include pain management, nutritional support and exercise therapy.

In this Special Issue, original research and reviews on advancements in diagnosis and treatment of multiple myeloma are welcome. Research areas may include (but are not limited) to the following:

• New imaging techniques including artificial-intelligence based systems in multiple myeloma.
• Novel biomarkers.
• Genetic and epigenomic profiling.
• Multiple myeloma therapy.
• Supportive care, e.g., pain management, nutrition, exercise.

We look forward to receiving your contributions.

Dr. Ulrike Dapunt
Guest Editor

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