Advances in Diagnostic Techniques and Endoscopic Management for Gastrointestinal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1002

Special Issue Editor


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Guest Editor
Department of Medicine, Division of Gastroenterology‐Hepatology, Albany Medical College, Albany, NY 12208, USA
Interests: gastroenterology; cholangioscopy; esophagogastric junction; biliary stones
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Special Issue Information

Dear Colleagues,

The evolution of contemporary endoscopy and colonoscopy occurred during the 1960s, signifying a considerable advancement in gastroenterology. The subsequent era has been characterized by significant progress, encompassing esophagogastroduodenoscopy (EGD), colonoscopy, deep enteroscopy, video capsule endoscopy, endoscopic ultrasound, and endoscopic retrograde cholangiopancreatography (ERCP). These procedures have since become standard practices within routine medical protocols. Ongoing refinements have introduced high-definition endoscopes, diverse optical options, and sophisticated sampling methodologies, in addition to advancements such as spyglass technology and motorized enteroscopy. The integration of artificial intelligence and deep learning has facilitated breakthroughs in numerous aspects of gastrointestinal disease diagnosis, with multiple platforms currently employed within community-based practices, and their applications are consistently expanding. Accompanying this technological expansion, the gastroenterology community has also focused on developing practice and establishing clear guidelines regarding the quality outcomes of all the aforementioned procedures.

Consequently, therapeutic endoscopy has also expanded, diminishing the necessity for surgical interventions and facilitating broader applications in techniques such as peroral endoscopic myotomy (POEMS) and endoscopic submucosal dissection (ESD). This progress has heralded a new era for postoperative endoscopic care and managing complications that may arise thereafter.

This Special Issue aims to disseminate reviews and research pertinent to advancements in Diagnostic Techniques and Endoscopic Management for Gastrointestinal Diseases.

Dr. Micheal Tadros
Guest Editor

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Keywords

  • endoscopy
  • gastrointestinal disease
  • diagnostic techniques

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Published Papers (1 paper)

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Research

14 pages, 1478 KB  
Article
Autoimmune Metaplastic Atrophic Gastritis Reporting: Are Pathologists and Endoscopists on the Same Page?
by Nicole Vienneau, Hwajeong Lee, Xulang Zhang, Eundong Park, Madeline Cleary, Jing Zhou, Shunsa Tarar, Meng Liu and Micheal Tadros
Diagnostics 2025, 15(22), 2906; https://doi.org/10.3390/diagnostics15222906 - 17 Nov 2025
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Abstract
Background/Objectives: Autoimmune metaplastic atrophic gastritis (AMAG) is a chronic, autoimmune-mediated condition associated with increased risk of malignancy and nutritional deficiencies, yet diagnostic and follow-up processes remain inconsistent and unclear. This study investigates follow-up testing performance in patients with AMAG and neuroendocrine tumors [...] Read more.
Background/Objectives: Autoimmune metaplastic atrophic gastritis (AMAG) is a chronic, autoimmune-mediated condition associated with increased risk of malignancy and nutritional deficiencies, yet diagnostic and follow-up processes remain inconsistent and unclear. This study investigates follow-up testing performance in patients with AMAG and neuroendocrine tumors (NET), as well as the correlation between endoscopic impressions and histologic findings. Methods: We retrospectively analyzed 65 gastric biopsies with final diagnoses or comments mentioning the possibility of AMAG, 12 of which included well-differentiated WHO grade 1 NET arising in AMAG. H&E slides were reviewed to assess atrophy severity, the presence or absence of enterochromaffin-like (ECL) cell hyperplasia, and Helicobacter organisms. The final diagnostic line or comments made were scored from 1 to 5, based on the strength of the language used to alert the treating clinician to the likelihood of AMAG. Corresponding endoscopy reports were scored from 1 to 5 based on the likelihood of the reports documenting AMAG features. Data regarding follow-up laboratory testing relevant to AMAG and biopsy performance were collected from the electronic medical records. Results: Endoscopy scores showed no significant associations with the histology comment score or atrophy grade. The histology comment score was positively associated with performing at least a total of three laboratory tests (p = 0.03). No association was found between the presence or absence of follow-up biopsy and histology comment score (p = 0.60). Follow-up biopsy was more common in patients with NET than those with AMAG without NET (p < 0.001). Conclusions: Poor endoscopic–histologic correlation with variable follow-up practices highlights the need for standardized protocols in AMAG management. Enhanced adherence to biopsy guidelines, standardized pathology reporting, and consistent surveillance, particularly for patients with AMAG without NET, are imperative to improve diagnosis and outcomes. Future research should focus on optimizing endoscopic techniques, standardizing serological tests, and establishing evidence-based surveillance protocols for AMAG patients. Full article
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