Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
3.6
Journals
Diagnostics
Special Issues
Recent Advances in Diagnosis and Treatment of Kidney Diseases
share announcement

Recent Advances in Diagnosis and Treatment of Kidney Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 6483

Special Issue Editor

Dr. Kenji Tsuji

E-Mail Website
Guest Editor
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Interests: renal development; kidney fibrosis; acute kidney injury; chronic kidney disease; regeneration; dialysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) is a global public health problem with a huge economic cost on healthcare systems worldwide. Since the early diagnosis and treatment of CKD may delay or prevent progression to advanced kidney disease, the advent of reliable biomarkers detecting early stages of kidney diseases, monitoring disease progression and prognostic values as well as novel therapies for kidney diseases is required. In the last decade, a number of advances have been made in the diagnosis and treatment of CKD and its variety of etiologies, including diabetic kidney disease, glomerulonephritis and polycystic kidney diseases. Regarding the treatment of CKD, beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitor on CKD patients have been demonstrated, and other promising drug candidates have been reported. In addition, research for renal replacement therapies of hemodialysis, peritoneal dialysis and renal regeneration is also progressing.

This Special Issue aims to improve our knowledge of recent advances in the diagnosis and treatment of kidney diseases. The scope covers a wide range of kidney diseases, including diabetic kidney disease, glomerulonephritis and polycystic kidney diseases. In this Special Issue, original research and reviews that offer suggestions for the better diagnosis and treatment of kidney diseases are welcome.

Dr. Kenji Tsuji
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • diabetic kidney disease
  • glomerulonephritis
  • polycystic kidney diseases
  • renal pathology
  • biomarker
  • kidney regeneration
  • hemodialysis
  • peritoneal dialysis
  • diagnosis

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 797 KiB  
Article
Point-of-Care Testing to Differentiate Various Acid–Base Disorders in Chronic Kidney Disease
by Tomasz Gołębiowski, Sławomir Zmonarski, Wiktoria Rożek, Mateusz Powązka, Patryk Jerzak, Maciej Gołębiowski, Mariusz Kusztal, Piotr Olczyk, Jakub Stojanowski, Krzysztof Letachowicz, Mirosław Banasik, Andrzej Konieczny and Magdalena Krajewska
Diagnostics 2023, 13(21), 3367; https://doi.org/10.3390/diagnostics13213367 - 2 Nov 2023
Viewed by 953
Abstract
Background: Normal-anion-gap metabolic acidosis (AGMA) and high-anion-gap metabolic acidosis (HAGMA) are two forms of metabolic acidosis, which is a common complication in patients with chronic kidney disease (CKD). The aim of this study is to identify the prevalence of various acid–base disorders in [...] Read more.
Background: Normal-anion-gap metabolic acidosis (AGMA) and high-anion-gap metabolic acidosis (HAGMA) are two forms of metabolic acidosis, which is a common complication in patients with chronic kidney disease (CKD). The aim of this study is to identify the prevalence of various acid–base disorders in patients with advanced CKD using point-of-care testing (POCT) and to determine the relationship between POCT parameters. Methods: In a group of 116 patients with CKD in stages G4 and G5, with a mean age of 62.5 ± 17 years, a sample of arterial blood was taken during the arteriovenous fistula procedure for POCT, which enables an assessment of the most important parameters of acid–base balance, including: pH, base excess (BE), bicarbonate (HCO3−), chloride(Cl−), anion gap (AG), creatinine and urea concentration. Based on this test, patients were categorized according to the type of acidosis-base disorder. Results: Decompensate acidosis with a pH < 7.35 was found in 68 (59%) patients. Metabolic acidosis (MA), defined as the concentration of HCO3− ≤ 22 mmol/L, was found in 92 (79%) patients. In this group, significantly lower pH, BE, HCO3− and Cl− concentrations were found. In group of MA patients, AGMA and HAGMA was observed in 48 (52%) and 44 (48%) of patients, respectively. The mean creatinine was significantly lower in the AGMA group compared to the HAGMA group (4.91 vs. 5.87 mg/dL, p < 0.05). The AG correlated positively with creatinine (r = 0.44, p < 0.01) and urea (r = 0.53, p < 0.01), but there was no correlation between HCO3− and both creatinine (r = −0.015, p > 0.05) and urea (r = −0.07, p > 0.05). The Cl− concentrations correlated negatively with HCO3− (r = −0.8, p < 0.01). Conclusions: The most common type of acid–base disturbance in CKD patients in stages 4 and 5 is AGMA, which is observed in patients with better kidney function and is associated with compensatory hyperchloremia. The initiation of renal replacement therapy was significantly earlier for patients diagnosed with HAGMA compared to those diagnosed with AGMA. The more advanced the CKD, the higher the AG. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Kidney Diseases)
►▼ Show Figures

Figure 1

14 pages, 3153 KiB  
Article
Automatic Identification of Glomerular in Whole-Slide Images Using a Modified UNet Model
by Gurjinder Kaur, Meenu Garg, Sheifali Gupta, Sapna Juneja, Junaid Rashid, Deepali Gupta, Asadullah Shah and Asadullah Shaikh
Diagnostics 2023, 13(19), 3152; https://doi.org/10.3390/diagnostics13193152 - 9 Oct 2023
Cited by 1 | Viewed by 975
Abstract
Glomeruli are interconnected capillaries in the renal cortex that are responsible for blood filtration. Damage to these glomeruli often signifies the presence of kidney disorders like glomerulonephritis and glomerulosclerosis, which can ultimately lead to chronic kidney disease and kidney failure. The timely detection [...] Read more.
Glomeruli are interconnected capillaries in the renal cortex that are responsible for blood filtration. Damage to these glomeruli often signifies the presence of kidney disorders like glomerulonephritis and glomerulosclerosis, which can ultimately lead to chronic kidney disease and kidney failure. The timely detection of such conditions is essential for effective treatment. This paper proposes a modified UNet model to accurately detect glomeruli in whole-slide images of kidney tissue. The UNet model was modified by changing the number of filters and feature map dimensions from the first to the last layer to enhance the model’s capacity for feature extraction. Moreover, the depth of the UNet model was also improved by adding one more convolution block to both the encoder and decoder sections. The dataset used in the study comprised 20 large whole-side images. Due to their large size, the images were cropped into 512 × 512-pixel patches, resulting in a dataset comprising 50,486 images. The proposed model performed well, with 95.7% accuracy, 97.2% precision, 96.4% recall, and 96.7% F1-score. These results demonstrate the proposed model’s superior performance compared to the original UNet model, the UNet model with EfficientNetb3, and the current state-of-the-art. Based on these experimental findings, it has been determined that the proposed model accurately identifies glomeruli in extracted kidney patches. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Kidney Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

20 pages, 1834 KiB  
Review
Diagnosing and Treating IgAN: Steroids, Budesonide, or Maybe Both?
by Christodoulos Keskinis, Eleni Moysidou, Michalis Christodoulou, Panagiotis Pateinakis and Maria Stangou
Diagnostics 2024, 14(5), 512; https://doi.org/10.3390/diagnostics14050512 - 28 Feb 2024
Viewed by 1244
Abstract
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, is characterized by a mesangial IgA deposit and a variety of histological lesions, as described by the Oxford classification system. Despite the well-described “four-hit hypothesis”, there are still plenty of less or undescribed mechanisms [...] Read more.
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, is characterized by a mesangial IgA deposit and a variety of histological lesions, as described by the Oxford classification system. Despite the well-described “four-hit hypothesis”, there are still plenty of less or undescribed mechanisms that participate in the disease pathogenesis, such as B-cell priming, which seems to be initiated by different antigens in the intestinal microbiota. Diagnosis of the disease is currently based on kidney biopsy findings, as the sensitivity and specificity of the many serum and urinary biomarkers described so far do not seem to have diagnostic accuracy. Therapeutic strategies consist of the initial step of non-immune medication, aiming to reduce both the intraglomerular pressure and proteinuria to below 0.5 g/day, followed by systemic corticosteroid administration in patients who remain at high risk for progressive chronic kidney disease despite the maximum non-immune treatment. The 6-month systemic corticosteroid treatment reduces proteinuria levels; however, the increased possibility of adverse events and increased relapse rate after treatment raises the need for a new therapeutic approach. Targeted-release budesonide is a therapeutic modality that aims to inhibit disease pathogenetic pathways at early stages; it has minor systemic absorption and proven beneficial effects on renal function and proteinuria. In the present systemic review, the benefits and adverse events of steroids and budesonide are described, and the possibility of combined treatment is questioned in selected cases with active histologic lesions. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Kidney Diseases)
►▼ Show Figures

Figure 1

24 pages, 4185 KiB  
Review
Unraveling Chronic Cardiovascular and Kidney Disorder through the Butterfly Effect
by Dimitri Bedo, Thomas Beaudrey and Nans Florens
Diagnostics 2024, 14(5), 463; https://doi.org/10.3390/diagnostics14050463 - 20 Feb 2024
Viewed by 1536
Abstract
Chronic Cardiovascular and Kidney Disorder (CCKD) represents a growing challenge in healthcare, characterized by the complex interplay between heart and kidney diseases. This manuscript delves into the “butterfly effect” in CCKD, a phenomenon in which acute injuries in one organ lead to progressive [...] Read more.
Chronic Cardiovascular and Kidney Disorder (CCKD) represents a growing challenge in healthcare, characterized by the complex interplay between heart and kidney diseases. This manuscript delves into the “butterfly effect” in CCKD, a phenomenon in which acute injuries in one organ lead to progressive dysfunction in the other. Through extensive review, we explore the pathophysiology underlying this effect, emphasizing the roles of acute kidney injury (AKI) and heart failure (HF) in exacerbating each other. We highlight emerging therapies, such as renin–angiotensin–aldosterone system (RAAS) inhibitors, SGLT2 inhibitors, and GLP1 agonists, that show promise in mitigating the progression of CCKD. Additionally, we discuss novel therapeutic targets, including Galectin-3 inhibition and IL33/ST2 pathway modulation, and their potential in altering the course of CCKD. Our comprehensive analysis underscores the importance of recognizing and treating the intertwined nature of cardiac and renal dysfunctions, paving the way for more effective management strategies for this multifaceted syndrome. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Kidney Diseases)
►▼ Show Figures

Figure 1

21 pages, 396 KiB  
Review
MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury
by Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura and Jun Wada
Diagnostics 2023, 13(18), 2893; https://doi.org/10.3390/diagnostics13182893 - 9 Sep 2023
Viewed by 1037
Abstract
Acute kidney injury (AKI) is a clinical syndrome where a rapid decrease in kidney function and/or urine output is observed, which may result in the imbalance of water, electrolytes and acid base. It is associated with poor prognosis and prolonged hospitalization. Therefore, an [...] Read more.
Acute kidney injury (AKI) is a clinical syndrome where a rapid decrease in kidney function and/or urine output is observed, which may result in the imbalance of water, electrolytes and acid base. It is associated with poor prognosis and prolonged hospitalization. Therefore, an early diagnosis and treatment to avoid the severe AKI stage are important. While several biomarkers, such as urinary L-FABP and NGAL, can be clinically useful, there is still no gold standard for the early detection of AKI and there are limited therapeutic options against AKI. miRNAs are non-coding and single-stranded RNAs that silence their target genes in the post-transcriptional process and are involved in a wide range of biological processes. Recent accumulated evidence has revealed that miRNAs may be potential biomarkers and therapeutic targets for AKI. In this review article, we summarize the current knowledge about miRNAs as promising biomarkers and potential therapeutic targets for AKI, as well as the challenges in their clinical use. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Kidney Diseases)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop