Animal Models for Diabetes Mellitus and Its Complications: Advantages and Limitations

A Special Issue of Diabetology (ISSN 2673-4540).

Deadline for manuscript submissions: 25 December 2026 | Viewed by 2531

Editor


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Guest Editor
Department of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland
Interests: animals; diabetes; blood; drug effects; therapeutic use; metabolism; pharmacology; obesity; lifestyle interventions

Special Issue Information

Dear Colleagues,

As guest editor of a Special Issue of the Diabetology journal entitled "Animal Models for Diabetes Mellitus and Its Complications: Advantages and Limitations", I invite you to submit original research articles, systematic reviews, and narrative reviews. This issue will place particular emphasis on evaluating the advantages and limitations of animal models used to study type 1 and type 2 diabetes, as well as their complications, such as nephropathy, retinopathy, neuropathy, and cardiomyopathy. Articles may analyze genetic, chemical, surgical, or dietary models and their usefulness in various aspects of translational research. Papers comparing models regarding pathophysiology, therapeutic efficacy, and application to preclinical research are particularly welcome. The deadline for paper submissions is 28 February 2026, and detailed instructions can be found on the issue's website. We encourage you to contribute to this interdisciplinary issue.

Dr. Emilia Sokolowska
Guest Editor

Manuscript Submission Information

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Keywords

  • animal models
  • diabetes mellitus
  • diabetic complications
  • insulin resistance
  • hyperglycemia
  • experimental diabetes
  • pathophysiology
  • translational research
  • preclinical models
  • diet-induced diabetes

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Published Papers (1 paper)

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Research

13 pages, 2343 KB  
Article
Treatment with Curcumin Delays the Development of Type 1 Diabetes Mellitus by Decreasing Proinflammatory Cytokines in Non-Obese Diabetic Mice
by Espiridión Ramos-Martínez, Ramcés Falfán-Valencia, Gloria Pérez-Rubio, Francisco Javier García-Vázquez, Jorge Rojas-Serrano, Anayántzin Paulina Heredia-Antúnez, Gerardo Aristi-Urista and Anahí Chavarria-Krauser
Diabetology 2026, 7(2), 31; https://doi.org/10.3390/diabetology7020031 - 2 Feb 2026
Viewed by 1786
Abstract
Background: This work aimed to determine whether curcumin influences the development of type 1 diabetes mellitus (DM) in a murine model. Methodology: Four groups of six non-obese diabetic (NOD) mice (A, B, C, and D) and one CD1 control group (E) were included. [...] Read more.
Background: This work aimed to determine whether curcumin influences the development of type 1 diabetes mellitus (DM) in a murine model. Methodology: Four groups of six non-obese diabetic (NOD) mice (A, B, C, and D) and one CD1 control group (E) were included. Groups A, B, and C received different doses of turmeric curcumin (50 mg/kg body weight (bw), 100 mg/kg bw, and 200 mg/kg bw, respectively) for six weeks, while groups D and E received only the vehicle simultaneously. Glycemia, body weight, and inflammatory infiltrate in the pancreatic islets were determined in all cases. Also, insulin and vitamin D receptor (VDR) expression in pancreatic cells was evaluated relative to the basal expression in the control (group E). Results: Glycemia in all the animals treated with curcumin remained stable from weeks 1 to 6, while the control group showed hyperglycemia (≥500 mg/dL) and weight loss (16.7 g ± 1 g). Treated animals had less inflammatory infiltrate, while maintaining insulin and VDR expression in the pancreas, compared with the control group. Finally, the serum concentrations of proinflammatory cytokines in treated animals were statistically lower than in the control group without curcumin. Conclusions: Curcumin delays the onset of T1DM and reduces pancreatic inflammatory infiltrate. Full article
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