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Dentistry Journal
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Advances in Regenerative Endodontics
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Advances in Regenerative Endodontics

A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Restorative Dentistry and Traumatology".

Deadline for manuscript submissions: 10 August 2026 | Viewed by 772

Special Issue Editors

Dr. José Luis Sanz

E-Mail Website
Guest Editor
Department of Stomatology, Faculty of Medicine and Dentistry, Universitat de València, Gascó Oliag 1, 46010 Valencia, Spain
Interests: regenerative endodontics; stem cells; dental materials; vital pulp treatment
Dr. Adrián Lozano

E-Mail Website
Guest Editor
Departament d'Estomatologia, Facultat de Medicina I Odontologia, Universitat de València, 46010 Valencia, Spain
Interests: regenerative endodontics; stem cells; dental materials; vital pulp treatment

Special Issue Information

Dear Colleagues,

In recent years, Regenerative Endodontics has undergone remarkable progress, supported by a deeper understanding of the biological processes underlying pulp-dentin complex regeneration and by advances in biomaterials, scaffolds, and stem cell biology.

The concept of biologically based endodontic treatment has evolved from traditional disinfection and obturation procedures toward minimally invasive approaches aimed at maintaining pulp vitality and promoting tissue repair or regeneration, whenever possible.

Within this scope, Vital Pulp Treatment has gained increasing attention as a biologically sound and clinically viable approach for the treatment of pulpitis, aimed at preserving reversibly affected tissue from the dentin-pulp complex and providing a favourable medium for its repair.

Moreover, ongoing developments in tissue engineering, growth factor delivery systems, and bioactive materials have expanded the potential for the Regenerative Endodontic Treatment of immature permanent teeth with pulp necrosis, offering new perspectives for both clinical practice and research.

The aim of this Special Issue is to provide an updated overview of the latest evidence and innovations in regenerative endodontics, highlighting how biologically based approaches are reshaping the future of dental tissue preservation and regeneration.

Dr. José Luis Sanz
Dr. Adrián Lozano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative endodontic treatment
  • vital pulp treatment
  • dental stem cells
  • dental biomaterials

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Published Papers (1 paper)

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10 pages, 3914 KB  
Case Report
Regeneration Versus Granulation Tissue Healing in a Hopeless Mature Mandibular Molar Post-Endodontic Management: A 40-Month Follow-Up Case Report
by Elhassan Hassanein, Petra Gierthmuehlen, Almaha S. Algazlan, Dalia Kaisarly and Moataz Elgezawi
Dent. J. 2026, 14(4), 243; https://doi.org/10.3390/dj14040243 - 20 Apr 2026
Viewed by 490
Abstract
Objective: To report a rare case of pulp space tissue growth in a mature mandibular molar with severe endo-periodontal involvement after conservative endodontic treatment and to discuss the possible biological explanations, including regeneration and granulation tissue healing. Severe endo-periodontal lesions are challenging, particularly [...] Read more.
Objective: To report a rare case of pulp space tissue growth in a mature mandibular molar with severe endo-periodontal involvement after conservative endodontic treatment and to discuss the possible biological explanations, including regeneration and granulation tissue healing. Severe endo-periodontal lesions are challenging, particularly as endodontic regeneration is usually observed in immature teeth, while revascularization in mature teeth, especially in cases of advanced periodontal disease, is rare, as demonstrated in this case. Methods: This study reports a rare case of tissue regeneration versus granulation tissue healing in the pulp space, occurring alongside periodontal healing, in a mature mandibular molar with necrotic pulp and severe periodontal involvement. A 52-year-old patient presented with a mature mandibular molar (tooth #19) exhibiting necrotic pulp with severe endo-periodontal involvement, including grade-3 mobility, tenderness to percussion, a 12 mm probing depth, and extensive periradicular radiolucency. The tooth was diagnosed with necrotic pulp and symptomatic apical periodontitis and was deemed hopeless, with extraction planned. Results: Following patient refusal, endodontic treatment was initiated, including cleaning, shaping, and placement of the intracanal medicament, Ledermix. The patient canceled the extraction due to symptom resolution and disappeared for 12 months. On return, the patient presented with spontaneous pain exacerbated by thermal stimuli, consistent with symptoms of irreversible pulpitis. Clinical examination revealed significant clinical and radiographic improvements, including reduced probing depth (3 mm), no mobility, resolution of apical translucency, radiographic findings suggestive of canal narrowing, and a positive pulp sensibility response. Re-entry elicited profuse bleeding with newly formed vital tissue beneath the medicament. Sodium hypochlorite irrigation failed to achieve hemostasis; inflamed tissue was removed; root canals were cleaned, shaped and obturated; and treatment was completed with placement of a permanent coronal resin composite restoration. A forty-month follow-up showed an asymptomatic tooth with clinical and radiographic healing. Conclusions: This case demonstrates that conservative endodontic management may result in favorable clinical and radiographic outcomes in mature teeth with severe endo-peroidontal involvement, influencing extraction decisions. It provides clinical evidence suggestive of tissue regeneration and periodontal healing in a mature tooth with necrotic pulp and severe periodontal compromise, challenging conventional prognosis. The observed pulp space tissue growth may be suggestive of regeneration; however, alternative explanations, including granulation tissue healing or repair processes, cannot be excluded. Healing by granulation tissue in the pulp space remains possible. Root canal treatment in advanced endo-perio lesions can yield favorable outcomes and may influence extraction decisions. Further clinical and histological studies are needed to clarify underlying mechanisms and optimize treatment strategies. Full article
(This article belongs to the Special Issue Advances in Regenerative Endodontics)
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